Rufinamide Related Compound B (25 mg) (Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate)
- Product Name
- Rufinamide Related Compound B (25 mg) (Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate)
- CAS No.
- 217448-86-7
- Chemical Name
- Rufinamide Related Compound B (25 mg) (Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate)
- Synonyms
- Rufinamide USP RC B;Lufeamide impurity 1;Rufinamide EP Impurity B;Rufinamide 4-Methyl Ester;RufinaMide Related CoMpound B;Rufinamide Methyl Ester Analog;Rufinamide USP Related Compound B;Methyl 1-(2,6-Difluorobenzyl)-1H-1,;methyl 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxylate;Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate
- CBNumber
- CB32567614
- Molecular Formula
- C11H9F2N3O2
- Formula Weight
- 253.2
- MOL File
- 217448-86-7.mol
Rufinamide Related Compound B (25 mg) (Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate) Property
- Melting point:
- 140℃ (methanol )
- Boiling point:
- 374.8±52.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -1.75±0.12(Predicted)
- color
- White to Off-White
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1S/C11H9F2N3O2/c1-18-11(17)10-6-16(15-14-10)5-7-8(12)3-2-4-9(7)13/h2-4,6H,5H2,1H3
- InChIKey
- XVEURJOWGBWEPY-UHFFFAOYSA-N
- SMILES
- N1(CC2=C(F)C=CC=C2F)C=C(C(OC)=O)N=N1
Safety
- WGK Germany
- WGK 3
- HS Code
- 2933998350
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- 1606423
- Product name
- Rufinamide Related Compound B
- Packaging
- 25mg
- Price
- $1210
- Updated
- 2026/03/19
- Product number
- D289555
- Product name
- 4-DescarboxamidoRufinamide4-MethylEster
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 5083DA
- Product name
- Methyl1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate
- Packaging
- 250mg
- Price
- $172
- Updated
- 2021/12/16
- Product number
- A258484
- Product name
- Methyl1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate
- Purity
- 98%
- Packaging
- 100mg
- Price
- $58
- Updated
- 2021/12/16
- Product number
- A258484
- Product name
- Methyl1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $88
- Updated
- 2021/12/16
Rufinamide Related Compound B (25 mg) (Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate) Chemical Properties,Usage,Production
Uses
4-Descarboxamido Rufinamide 4-Methyl Ester is an impurity in the synthesis of Rufinamide (R701550), an antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant.
Synthesis
106308-60-5
922-67-8
217448-86-7
Example 7: Synthesis of compound (II) Synthesis of methyl 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylate: 2,6-difluorobenzyl azide (3.0 g, 17.7 mmol) was suspended in ethanol (30 ml), followed by the addition of methyl propargylate (1.6 g, 19.6 mmol), ascorbic acid (317 mg, 1.8 mmol) and copper sulfate pentahydrate ( 50 mg, 0.18 mmol). The reaction mixture was stirred at 25°C overnight. After completion of the reaction, the mixture was concentrated, dissolved in ethyl acetate and the resulting solution was washed with ammonia. The organic phase was dried, filtered and concentrated under reduced pressure to give a white crystalline solid in 94% yield. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 8.86 (s, 1H), 7.52 (m, 1H), 7.27-7.12 (m, 2H), 5.74 (s, 2H), 3.83 (s, 3H).
References
[1] Patent: US2010/234616, 2010, A1. Location in patent: Page/Page column 3
[2] Patent: EP2230234, 2010, A1. Location in patent: Page/Page column 7
[3] ChemSusChem, 2015, vol. 8, # 3, p. 504 - 512
[4] Patent: WO2010/43849, 2010, A1. Location in patent: Page/Page column 13
[5] Tetrahedron Letters, 2013, vol. 54, # 26, p. 3406 - 3409
Rufinamide Related Compound B (25 mg) (Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate) Preparation Products And Raw materials
Raw materials
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View Lastest Price from Rufinamide Related Compound B (25 mg) (Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate) manufacturers
- Product
- Rufinamide Related Compound B (25 mg) (Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate) 217448-86-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-21