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Methyl 4-(2-broMophenyl)-2,4-dioxobutanoate

Product Name
Methyl 4-(2-broMophenyl)-2,4-dioxobutanoate
CAS No.
1035235-10-9
Chemical Name
Methyl 4-(2-broMophenyl)-2,4-dioxobutanoate
Synonyms
Methyl 4-(2-bromophenyl);Methyl 2-bromo-α,γ-dioxobenzenebutanoate;Methyl 2-bromo-α,γ-dioxobenzenebutanoate;Methyl 2-bromo-a,g-dioxo-benzenebutanoate;4-(2-Bromo-phenyl)-2,4-dioxo-butyric acid methyl ester;Benzenebutanoic acid, 2-bromo-α,γ-dioxo-, methyl ester
CBNumber
CB32570951
Molecular Formula
C11H9BrO4
Formula Weight
285.09
MOL File
1035235-10-9.mol
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Methyl 4-(2-broMophenyl)-2,4-dioxobutanoate Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
M296748
Product name
Methyl4-(2-Bromophenyl)-2,4-dioxobutanoate
Packaging
50mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
1168DE
Product name
Methyl4-(2-bromophenyl)-2,4-dioxobutanoate
Packaging
250mg
Price
$295
Updated
2021/12/16
AK Scientific
Product number
1168DE
Product name
Methyl4-(2-bromophenyl)-2,4-dioxobutanoate
Packaging
500mg
Price
$321
Updated
2021/12/16
AK Scientific
Product number
1168DE
Product name
Methyl4-(2-bromophenyl)-2,4-dioxobutanoate
Packaging
1g
Price
$345
Updated
2021/12/16
Matrix Scientific
Product number
181065
Product name
4-(2-Bromophenyl)-2,4-dioxobutyric acid methyl ester
Purity
95%+
Packaging
1g
Price
$371
Updated
2021/12/16
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Methyl 4-(2-broMophenyl)-2,4-dioxobutanoate Chemical Properties,Usage,Production

Synthesis

553-90-2

2142-69-0

1035235-10-9

Step 1: Sodium metal (120 mg, 5.1 mmol) was slowly added to methanol (2.5 mL, 62 mmol) at -5 °C. Subsequently, a solution of dimethyl oxalate (500 mg, 4.2 mmol) and 2-bromoacetophenone (840 mg, 4.2 mmol) in ether (5 mL) was added to this solution. The reaction mixture was stirred at room temperature for 12 hours and then concentrated. The concentrate was partitioned between ether and water, the aqueous layer was separated and cooled in an ice bath. Acetic acid and 1N hydrochloric acid were added sequentially to the cooled aqueous layer until the solution became acidic. The mixture was extracted with ether, the organic layers were combined and dried over anhydrous sodium sulfate. After filtration, the organic layer was concentrated to give methyl 4-(2-bromophenyl)-2,4-dioxobutanoate (1.08 g, 89% yield), which could be used in the next reaction without further purification.LCMS(FA)ES+ m/z: 287.0 [M+H]+.

References

[1] Patent: US2008/171754, 2008, A1. Location in patent: Page/Page column 97
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 3, p. 1207 - 1216

Methyl 4-(2-broMophenyl)-2,4-dioxobutanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-(2-broMophenyl)-2,4-dioxobutanoate Suppliers

China 26 India 1 United States 3 Global 30
RuiErKang Pharmaceuticals, Inc.
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ShangHai AmK Pharmaceutical Technology Co., Ltd.
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微信 17321281695 18019252918
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Zhengzhou Guancheng Laboratory equipment Sales
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Taian Jiaye Biotechnology Co.Ltd
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Aikon International Limited
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1035235-10-9, Methyl 4-(2-broMophenyl)-2,4-dioxobutanoateRelated Search:


  • Benzenebutanoic acid, 2-bromo-α,γ-dioxo-, methyl ester
  • Methyl 4-(2-bromophenyl)
  • Methyl 2-bromo-a,g-dioxo-benzenebutanoate
  • 4-(2-Bromo-phenyl)-2,4-dioxo-butyric acid methyl ester
  • Methyl 2-bromo-α,γ-dioxobenzenebutanoate
  • Methyl 2-bromo-α,γ-dioxobenzenebutanoate
  • 1035235-10-9