3-chloropyrazine-2-carboxaMide
- Product Name
- 3-chloropyrazine-2-carboxaMide
- CAS No.
- 21279-62-9
- Chemical Name
- 3-chloropyrazine-2-carboxaMide
- Synonyms
- 3-Chloro-2-pyrazinecarboxaMide;3-chloropyrazine-2-carboxaMide;2-Pyrazinecarboxamide, 3-chloro-;3-Chloro-pyrazine-2-carboxylic acid amide
- CBNumber
- CB32574555
- Molecular Formula
- C5H4ClN3O
- Formula Weight
- 157.56
- MOL File
- 21279-62-9.mol
3-chloropyrazine-2-carboxaMide Property
- Melting point:
- 187.0 to 191.0 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- color
- White to Orange to Green
Safety
- HS Code
- 2933.99.8290
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C3376
- Product name
- 3-Chloropyrazine-2-carboxamide
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 200mg
- Price
- $46
- Updated
- 2026/03/19
- Product number
- C3376
- Product name
- 3-Chloropyrazine-2-carboxamide
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $136
- Updated
- 2026/03/19
- Product number
- B405290
- Product name
- 3-Chloropyrazine-2-carboxamide
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC140084
- Product name
- 3-Chloropyrazine-2-carboxamide
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FC140084
- Product name
- 3-Chloropyrazine-2-carboxamide
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
3-chloropyrazine-2-carboxaMide Chemical Properties,Usage,Production
Synthesis
55557-52-3
21279-62-9
Two methods for the synthesis of 3-chloropyrazine-2-carboxamide from 2-chloro-3-cyanopyrazine are described below: The first method is based on the homolytic amidation reaction of 2-chloropyrazine, which is less effective. The procedure was as follows: 2-chloropyrazine (0.17 mol) was dissolved in formamide (3.7 mol), heated to 90 °C, and then ammonium peroxydisulfate (0.18 mol) was added in batches over a period of 1 hour. The reaction mixture was continued at 90 °C for 1 h, followed by standing for 24 h at room temperature. Upon completion of the reaction, the mixture was diluted with 100 mL of water, filtered, and the filtrate was continuously extracted with chloroform for 16 hours. A mixture of three positional isomers was obtained by rapid chromatography on silica gel stationary phase. The second method used the partial hydrolysis reaction of 3-chloropyrazine-2-carbonitrile. The procedure was as follows: powdered 3-chloropyrazine-2-carbonitrile (0.104 mol) was slowly added to a mixture of concentrated hydrogen peroxide (0.95 mol) and water (195 mL) heated to 50 °C. The pH of the reaction mixture was adjusted to about 9 with 8% sodium hydroxide solution and the reaction temperature was maintained between 55 and 60°C. The reaction was stopped after 2.5 hours and cooled to 5°C. The precipitated crystals were collected by diafiltration and purified by recrystallization with ethanol.
References
[1] Molecules, 2014, vol. 19, # 7, p. 9318 - 9338
[2] Molecules, 2017, vol. 22, # 2,
3-chloropyrazine-2-carboxaMide Preparation Products And Raw materials
Raw materials
Preparation Products
3-chloropyrazine-2-carboxaMide Suppliers
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 025-83697070 13770331960
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16059
- Advantage
- 64
- Tel
- 13472757003
- Fax
- +86 21 64968087
- yongnan.wang@cendrix.cn
- Country
- China
- ProdList
- 962
- Advantage
- 65
- Tel
- 13761987713
- Fax
- 021 51613951
- hxzheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8667
- Advantage
- 57
- Tel
- 18993961550 18993966060
- Fax
- 0943-8288977
- sales@techbiochem.com
- Country
- China
- ProdList
- 796
- Advantage
- 61
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39999
- Advantage
- 60
View Lastest Price from 3-chloropyrazine-2-carboxaMide manufacturers
- Product
- 3-chloropyrazine-2-carboxaMide 21279-62-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-11-13
- Product
- 3-Chloropyrazine-2-carboxamide 21279-62-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.3%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- 3-chloropyrazine-2-carboxaMide 21279-62-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-20