ChemicalBook > CAS DataBase List > N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMine

N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMine

Product Name
N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMine
CAS No.
1353979-43-7
Chemical Name
N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMine
Synonyms
Compound8(C8);TRPM4 inhibitor 8;Brophenexin (free base);NMDAR/TRPM4 inhibitor 8;NMDAR/TRPM4-IN-2 (free base);TRPM4 inhibitor 8, 10 mM in DMSO;NMDAR/TRPM4 inhibitor 8 (Compound 8);(2-aminoethyl)[(3-bromophenyl)methyl]ethylamine;N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMine;N'-[(3-bromophenyl)methyl]-N'-ethylethane-1,2-diamine
CBNumber
CB32581603
Molecular Formula
C11H17BrN2
Formula Weight
257.17
MOL File
1353979-43-7.mol
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N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMine Property

Boiling point:
300.6±22.0 °C(Predicted)
Density 
1.293±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
form 
Liquid
pka
9.56±0.10(Predicted)
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
7436DS
Product name
N*1*-(3-Bromo-benzyl)-N*1*-ethyl-ethane-1,2-diamine
Packaging
1g
Price
$1121
Updated
2021/12/16
AK Scientific
Product number
7436DS
Product name
N*1*-(3-Bromo-benzyl)-N*1*-ethyl-ethane-1,2-diamine
Packaging
5g
Price
$3060
Updated
2021/12/16
AK Scientific
Product number
7436DS
Product name
N*1*-(3-Bromo-benzyl)-N*1*-ethyl-ethane-1,2-diamine
Packaging
10g
Price
$4492
Updated
2021/12/16
Crysdot
Product number
CD12151591
Product name
N1-(3-Bromobenzyl)-N1-ethylethane-1,2-diamine
Purity
97%
Packaging
1g
Price
$1378
Updated
2021/12/16
DC Chemicals
Product number
020505
Product name
NMDAR/TRPM4inhibitor8(Compound8)
Packaging
001
Price
$650
Updated
2021/12/16
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N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMine Chemical Properties,Usage,Production

Uses

Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].

IC 50

NMDA Receptor

References

[1] Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513):eaay3302. DOI:10.1126/science.aay3302

N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMine Suppliers

China 27 United States 3 Global 30
Amber MolTech LLC
Tel
086-010-62176588
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086-010-62117849
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amber@jyamber.com
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China
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Shanghai Raise Chemical Technology Co.,Ltd
Tel
15026594951
Fax
0556-5030632
Email
rs@raise-chem.com
Country
China
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4621
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
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Henan Alfachem Co.,Ltd.
Tel
0371-55051623 18137891487
Fax
QQ：2853979817
Email
3983243027@qq.com
Country
China
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Shanghai Thunder Biological Technology Co., Ltd.
Tel
18621609968
Email
1162686636@qq.com
Country
China
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930
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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Nextpeptide Inc
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+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
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China
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19908
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DC Chemicals
Tel
021-58447131 13564518121
Email
doncunbiosci@gmail.com
Country
China
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544
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Jingmo (Xiamen) Biotechnology Co., Ltd
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13621943973; 13621943973
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sales@jamxmpharmatech.com
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China
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1353979-43-7, N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMineRelated Search:


  • N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMine
  • N'-[(3-bromophenyl)methyl]-N'-ethylethane-1,2-diamine
  • NMDAR/TRPM4 inhibitor 8 (Compound 8)
  • NMDAR/TRPM4 inhibitor 8
  • NMDAR/TRPM4-IN-2 (free base)
  • TRPM4 inhibitor 8
  • 1,2-Ethanediamine, N1-[(3-bromophenyl)methyl]-N1-ethyl-
  • (2-aminoethyl)[(3-bromophenyl)methyl]ethylamine
  • Compound8(C8)
  • TRPM4 inhibitor 8, 10 mM in DMSO
  • Brophenexin (free base)
  • 1353979-43-7