(±)17-HETE
- Product Name
- (±)17-HETE
- CAS No.
- 128914-47-6
- Chemical Name
- (±)17-HETE
- Synonyms
- (±)17-HETE;OPPIPPRXLIDJKN-JPURVOHMSA-N;17-hydroxy-5(Z),8(Z),11(Z),14(Z)-ETA;17-hydroxy-5(Z),8(Z),11(Z),14(Z)-eicosatetraenoic acid;5,8,11,14-Eicosatetraenoic acid, 17-hydroxy-, (5Z,8Z,11Z,14Z)-
- CBNumber
- CB32589795
- Molecular Formula
- C20H32O3
- Formula Weight
- 320.47
- MOL File
- 128914-47-6.mol
(±)17-HETE Property
- storage temp.
- Store at -20°C
- solubility
- 0.1 m Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
N-Bromosuccinimide Price
- Product number
- 10010636
- Product name
- (±)17-HETE
- Purity
- ≥98%
- Packaging
- 25μg
- Price
- $146
- Updated
- 2024/03/01
- Product number
- 10010636
- Product name
- (±)17-HETE
- Purity
- ≥98%
- Packaging
- 50μg
- Price
- $278
- Updated
- 2024/03/01
- Product number
- 10010636
- Product name
- (±)17-HETE
- Purity
- ≥98%
- Packaging
- 100μg
- Price
- $525
- Updated
- 2024/03/01
(±)17-HETE Chemical Properties,Usage,Production
Description
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-
Uses
17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy[1][2].
Definition
ChEBI: A HETE that consists of arachidonic acid bearing an additional hydroxy substituent at position 17.
in vivo
17-HETE (1-20 μg, i.a.) stereospecificially inhibits proximal tubule ATPase activity with S- enantiomer in New Zealand white rabbit[2].
| Animal Model: | New Zealand White rabbit[2] |
| Dosage: | 1-20 μg |
| Administration: | injection into artery |
| Result: | 17S inhibited more than 70% ATPase activity at the concentration of 2 μM, while 17R enantiomer remained inactive. |
IC 50
CYP1B1
References
[1] Isse FA, et al., 17-(R/S)-hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins Other Lipid Mediat. 2023 Oct;168:106749. DOI:10.1016/j.prostaglandins.2023.106749
[2] Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9. DOI:10.1152/ajpregu.1996.271.4.R863
(±)17-HETE Preparation Products And Raw materials
Raw materials
Preparation Products
(±)17-HETE Suppliers
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 12952
- Advantage
- 65
- Tel
- 0717-6449896 13886658719
- Fax
- 0717-6558598
- root@zhongyitai.com
- Country
- China
- ProdList
- 1978
- Advantage
- 58
- Tel
- 1-516-6625404
- Fax
- 1-516-927-0118
- support@alfa-chemistry.com
- Country
- United States
- ProdList
- 9171
- Advantage
- 60
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 4006800868;027-59626688 18371453821;18771149750
- sales@amyjet.com
- Country
- China
- ProdList
- 2917
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24964
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11973
- Advantage
- 58
- Tel
- 15102117276 19921389125
- tech@zzbioco.com
- Country
- China
- ProdList
- 12064
- Advantage
- 58