ATB-343

Product Name: ATB-343
CAS No.: 1000700-26-4
Chemical Name: ATB-343
Synonyms: ATB-343;ATB-343 Exclusive;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester
CBNumber: CB32590306
Molecular Formula: C28H20ClNO4S3
Formula Weight: 566.11
MOL File: 1000700-26-4.mol

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ATB-343 Property

Boiling point:: 706.3±70.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13045
Product name: ATB-343
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 13045
Product name: ATB-343
Purity: ≥98%
Packaging: 5mg
Price: $155
Updated: 2024/03/01

Cayman Chemical

Product number: 13045
Product name: ATB-343
Purity: ≥98%
Packaging: 10mg
Price: $274
Updated: 2024/03/01

Cayman Chemical

Product number: 13045
Product name: ATB-343
Purity: ≥98%
Packaging: 50mg
Price: $1189
Updated: 2024/03/01

TRC

Product number: A790538
Product name: ATB-343
Packaging: 1mg
Price: $45
Updated: 2021/12/16

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ATB-343 Chemical Properties,Usage,Production

Uses

ATB-343 is a hybrid molecule of the NSAID indomethacinan and an H2S donor.

Biological Activity

atb-343, also named as indomethacin, is an h2s-releasing derivative of indomethacin [1].hydrogen sulfide (h2s) is a newly recognized signaling molecule with potent cytoprotective actions. hydrogen sulfide has been involved in mediating many physiological processes, such as the maintenance of gastrointestinal mucosal defense and repair. hydrogen sulfide also exerts many anti-inflammatory effects, including inhibition of leukocyte adherence to the vascular endothelium and leukocyte migration to sites of inflammation [2].

in vitro

indomethacin enhanced the nk cell activity in vitro by blocking the prostaglandin production of monocytes [3].

in vivo

in rats, oral administration of atb-343 significantly inhibited gastric prostaglandin synthesis and systemic cox-1 activity [1]. indomethacin was a potent inhibitor of prostaglandin synthesis. indomethacin suppressed in vivo thyroid hormone secretion and cholera toxin-induced intestinal fluid accumulation. indomethacin in submicromolar concentrations inhibited cyclic amp-dependent protein kinase and endogenous protein phosphorylation [4].

References

[1] wallace j l. hydrogen sulfide-releasing anti-inflammatory drugs[j]. trends in pharmacological sciences, 2007, 28(10): 501-505.
[2] wallace j l. physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tract[j]. antioxidants & redox signaling, 2010, 12(9): 1125-1133.
[3] pedersen b k, oxholm p, klarlund k. characterization of the in vivo and in vitro effects of indomethacin on human natural killer cell activity[j]. allergy, 1986, 41(7): 532-536.
[4] kantor h s, hampton m. indomethacin in submicromolar concentrations inhibits cyclic amp-dependent protein kinase[j]. 1978.
[5] rogers j, kirby l c, hempelman s r, et al.

ATB-343 Preparation Products And Raw materials

Raw materials

Preparation Products

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ATB-343 Suppliers

Canada 1 CHINA 28 United States 4 Global 33

Shanghai EFE Biological Technology Co., Ltd.

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Alfa Chemistry

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Energy Chemical

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MedBioPharmaceutical Technology Inc

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Cayman Chemical Company

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Santa Cruz Biotechnology Inc

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ApexBio Technology

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Shanghai Shitang Industrial Co., Ltd.

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Guangzhou Yiran Biotechnology Co., Ltd.

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1000700-26-4, ATB-343Related Search:

ATB-343

ATB-343 Exclusive

1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester

1000700-26-4

C28H20ClNO4S3