CAY10589

Product Name: CAY10589
CAS No.: 1077626-52-8
Chemical Name: CAY10589
Synonyms: CAY10589;CAY10589 Exclusive;FQMPYBCEABTPIK-UHFFFAOYSA-N;Octanoic acid, 2-[[4-[([1,1'-biphenyl]-4-ylmethyl)amino]-6-chloro-2-pyrimidinyl]thio]-
CBNumber: CB32590432
Molecular Formula: C25H28ClN3O2S
Formula Weight: 470.03
MOL File: 1077626-52-8.mol

More

Less

CAY10589 Property

Boiling point:: 648.1±55.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form: A crystalline solid
pka: 3.04±0.21(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 13164
Product name: CAY10589
Purity: ≥98%
Packaging: 1mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 13164
Product name: CAY10589
Purity: ≥98%
Packaging: 5mg
Price: $236
Updated: 2024/03/01

Cayman Chemical

Product number: 13164
Product name: CAY10589
Purity: ≥98%
Packaging: 10mg
Price: $420
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: HCH0069391
Product name: 2-((4-(((1,1'-BIPHENYL)-4-YLMETHYL)AMINO)-6-CHLORO-2-PYRIMIDINYL)THIO)-OCTANOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $499.99
Updated: 2021/12/16

AK Scientific

Product number: 2947DC
Product name: 2-[4-Chloro-6-[(4-phenylphenyl)methylamino]pyrimidin-2-yl]sulfanyloctanoicacid
Packaging: 10mg
Price: $564
Updated: 2021/12/16

More

Less

CAY10589 Chemical Properties,Usage,Production

Description

Microsomal Prostaglandin E₂ Synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE₂, which is directly involved in signaling during inflammation, fever and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. CAY10589 is a dual inhibitor of mPGES-1 (IC₅₀ = 1.3 μM) and 5-LO (IC₅₀ = 1.0 μM). It effectively inhibits PGE₂ and LT synthesis in both cell free and intact cell assays. CAY10589 has minor effects on COX-1 and COX-2, inhibiting these enzymes 34% and 38.8%, respectively, at 10 μM.

Uses

CAY10589 is an inhibitor of mPGES-1, an enzyme induced during inflammatory responses. CAY10589 has no significant effect on the differentiation of BM myeloid precursor cells into M2-like TAMs[1][2].

Definition

ChEBI: CAY10589 is a member of biphenyls.

References

[1] Wiegard A, et al. Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1. Eur J Med Chem. 2012 Feb;48:153-63. DOI:10.1016/j.ejmech.2011.12.009
[2] Li L, et al. Targeting the lipid metabolic reprogramming of tumor-associated macrophages: A novel insight into cancer immunotherapy. Cell Oncol (Dordr). 2023 Sep 30. DOI:10.1007/s13402-023-00881-y

CAY10589 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CAY10589 Suppliers

China 25 United States 3 Global 28

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24964
Advantage: 58

Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7982
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Guangzhou Weisheng Biotechnology Co., Ltd.

Tel: 17765667235
Country: CHINA
ProdList: 129
Advantage: 58

Foshan Minghua Biotechnology Co., Ltd.

Tel: 18312287787
Country: CHINA
ProdList: 196
Advantage: 58

1077626-52-8, CAY10589Related Search:

CAY10589

CAY10589 Exclusive

FQMPYBCEABTPIK-UHFFFAOYSA-N

Octanoic acid, 2-[[4-[([1,1'-biphenyl]-4-ylmethyl)amino]-6-chloro-2-pyrimidinyl]thio]-

1077626-52-8