JZL 195

ChemicalBook > CAS DataBase List > JZL 195

Product Name: JZL 195
CAS No.: 1210004-12-8
Chemical Name: JZL 195
Synonyms: CS-1586;JZL 195;JZL-195;JZL 195;JZL195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester;Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195
CBNumber: CB32591530
Molecular Formula: C24H23N3O5
Formula Weight: 433.46
MOL File: 1210004-12-8.mol

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JZL 195 Property

Boiling point:: 581.8±50.0 °C(Predicted)
Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: ≥5mg/mL at warmed
pka: 6.13±0.10(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H400Very toxic to aquatic life
Precautionary statements: P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0257
Product name: JZL195
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $127
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0257
Product name: JZL195
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $491
Updated: 2024/03/01

Cayman Chemical

Product number: 13668
Product name: JZL 195
Purity: ≥98%
Packaging: 5mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 13668
Product name: JZL 195
Purity: ≥98%
Packaging: 10mg
Price: $112
Updated: 2024/03/01

Cayman Chemical

Product number: 13668
Product name: JZL 195
Purity: ≥98%
Packaging: 50mg
Price: $468
Updated: 2024/03/01

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JZL 195 Chemical Properties,Usage,Production

Description

Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC₅₀s = 2 and 4 nM, respectively). It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation. The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 and JZL 184 , respectively. Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB₁ agonists.

Uses

JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.

storage

Store at -20°C

JZL 195 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from JZL 195 manufacturers

Career Henan Chemical Co

Product: JZL 195 1210004-12-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2020-03-05

1210004-12-8, JZL 195Related Search:

JZL 195

4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester

CS-1586

JZL-195;JZL 195;JZL195

1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester

4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate

Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195

1210004-12-8

Inhibitors

API