Caspase-3/7 Inhibitor I

Product Name: Caspase-3/7 Inhibitor I
CAS No.: 220509-74-0
Chemical Name: Caspase-3/7 Inhibitor I
Synonyms: MMPSI;abs814634;MMPSI, 10 mM in DMSO;(S)-Caspase-3/7 Inhibitor I;MMPSI, Caspase-3/7 Inhibitor I;MMPSI, Caspase-3/7 Inhibitor I, caspase 3 and 7 inhibitor;5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2;(S)-5-((2-(Methoxymethyl)pyrrolidin-1-yl)sulfonyl)indoline-2,3-dione;5-[(2S)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]SULFONYL-1H-INDOLE-2;3-DIONE;1H-Indole-2,3-dione, 5-[[(2S)-2-(methoxymethyl)-1-pyrrolidinyl]sulfonyl]-
CBNumber: CB32596227
Molecular Formula: C14H16N2O5S
Formula Weight: 324.35
MOL File: 220509-74-0.mol

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Caspase-3/7 Inhibitor I Property

Density: 1.415±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥16.2 mg/mL in DMSO; ≥2.17 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 8.66±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 218826
Product name: Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem
Purity: The Caspase-3/7 Inhibitor I, also referenced under CAS 220509-74-0, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging: 1MG
Price: $172
Updated: 2024/03/01

ApexBio Technology

Product number: A1925
Product name: Caspase-3/7InhibitorI
Packaging: 10mg
Price: $375
Updated: 2021/12/16

ApexBio Technology

Product number: A1925
Product name: Caspase-3/7InhibitorI
Packaging: 25mg
Price: $600
Updated: 2021/12/16

ApexBio Technology

Product number: A1925
Product name: Caspase-3/7InhibitorI
Packaging: 1unit
Price: $28
Updated: 2021/12/16

ApexBio Technology

Product number: A1925
Product name: Caspase-3/7InhibitorI
Packaging: 1mg
Price: $85
Updated: 2021/12/16

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Caspase-3/7 Inhibitor I Chemical Properties,Usage,Production

Uses

MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection[1].

Biological Activity

caspase-3/7 inbibitor i is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (ki(app) = 60 nm) and caspase-7 (ki(app) = 170 nm). is a weaker inhibitor of caspase-9 (ki(app) = 3.1 mm). it has only a trivial effect (ki(app) >25 mm) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. it has been shown to inhibit apoptosis in camptothecin treated jurkat cells (ic50 ~50 μm). also it has been reported to inhibit apoptosis in chondrocytes (44% inhibition at 10 μm and 98% inhibition at 50 μm). selectivity for caspases-3 and 7 involves unique hydrophobic residues in the s2 pocket surrounding the catalytic cysteine residue. [1] [2] in some systems inhibition of caspases-3 and -7 can prevent apoptosis and may therefore have important therapeutic implications. [3]a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (ki = 60 nm) and caspase-7 (ki = 170 nm).

target

Caspase-3

IC 50

human Caspase-3: 1.7 μM (IC₅₀)

References

1. lee, d., et al. 2001. j. med. chem. 44, 2015. 2. lee, d., et al. 2000. j. biol. chem. 275, 16007. 3. clements, k. m., burton‐wurster, n., nuttall, m. e., & lust, g. (2005). caspase‐3/7 inhibition alters cell morphology in mitomycin‐c treated chondrocytes. journal of cellular physiology, 205(1), 133-140.

Caspase-3/7 Inhibitor I Preparation Products And Raw materials

Raw materials

Preparation Products

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Caspase-3/7 Inhibitor I Suppliers

China 21 United States 6 Global 27

AdooQ BioScience, LLC

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220509-74-0

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