Caspase-3/7 Inhibitor I
- Product Name
- Caspase-3/7 Inhibitor I
- CAS No.
- 220509-74-0
- Chemical Name
- Caspase-3/7 Inhibitor I
- Synonyms
- MMPSI;abs814634;MMPSI, 10 mM in DMSO;(S)-Caspase-3/7 Inhibitor I;MMPSI, Caspase-3/7 Inhibitor I;MMPSI, Caspase-3/7 Inhibitor I, caspase 3 and 7 inhibitor;5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2;(S)-5-((2-(Methoxymethyl)pyrrolidin-1-yl)sulfonyl)indoline-2,3-dione;5-[(2S)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]SULFONYL-1H-INDOLE-2;3-DIONE;1H-Indole-2,3-dione, 5-[[(2S)-2-(methoxymethyl)-1-pyrrolidinyl]sulfonyl]-
- CBNumber
- CB32596227
- Molecular Formula
- C14H16N2O5S
- Formula Weight
- 324.35
- MOL File
- 220509-74-0.mol
Caspase-3/7 Inhibitor I Property
- Density
- 1.415±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥16.2 mg/mL in DMSO; ≥2.17 mg/mL in EtOH with gentle warming and ultrasonic
- form
- solid
- pka
- 8.66±0.20(Predicted)
- color
- Light yellow to yellow
- InChI
- 1S/C14H16N2O5S/c1-21-8-9-3-2-6-16(9)22(19,20)10-4-5-12-11(7-10)13(17)14(18)15-12/h4-5,7,9H,2-3,6,8H2,1H3,(H,15,17,18)/t9-/m0/s1
- InChIKey
- SLQMNVJNDYLJSF-VIFPVBQESA-N
Safety
- WGK Germany
- WGK 1
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 218826
- Product name
- Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem
- Purity
- The Caspase-3/7 Inhibitor I, also referenced under CAS 220509-74-0, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.
- Packaging
- 1MG
- Price
- $172
- Updated
- 2024/03/01
- Product number
- A1925
- Product name
- Caspase-3/7InhibitorI
- Packaging
- 10mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- A1925
- Product name
- Caspase-3/7InhibitorI
- Packaging
- 25mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- A1925
- Product name
- Caspase-3/7InhibitorI
- Packaging
- 1unit
- Price
- $28
- Updated
- 2021/12/16
- Product number
- A1925
- Product name
- Caspase-3/7InhibitorI
- Packaging
- 1mg
- Price
- $85
- Updated
- 2021/12/16
Caspase-3/7 Inhibitor I Chemical Properties,Usage,Production
Uses
MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection[1].
Biological Activity
caspase-3/7 inbibitor i is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (ki(app) = 60 nm) and caspase-7 (ki(app) = 170 nm). is a weaker inhibitor of caspase-9 (ki(app) = 3.1 mm). it has only a trivial effect (ki(app) >25 mm) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. it has been shown to inhibit apoptosis in camptothecin treated jurkat cells (ic50 ~50 μm). also it has been reported to inhibit apoptosis in chondrocytes (44% inhibition at 10 μm and 98% inhibition at 50 μm). selectivity for caspases-3 and 7 involves unique hydrophobic residues in the s2 pocket surrounding the catalytic cysteine residue. [1] [2] in some systems inhibition of caspases-3 and -7 can prevent apoptosis and may therefore have important therapeutic implications. [3]a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (ki = 60 nm) and caspase-7 (ki = 170 nm).
target
Caspase-3
IC 50
human Caspase-3: 1.7 μM (IC50)
References
1. lee, d., et al. 2001. j. med. chem. 44, 2015. 2. lee, d., et al. 2000. j. biol. chem. 275, 16007. 3. clements, k. m., burton‐wurster, n., nuttall, m. e., & lust, g. (2005). caspase‐3/7 inhibition alters cell morphology in mitomycin‐c treated chondrocytes. journal of cellular physiology, 205(1), 133-140.
Caspase-3/7 Inhibitor I Preparation Products And Raw materials
Raw materials
Preparation Products
Caspase-3/7 Inhibitor I Suppliers
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
- Advantage
- 58
- Tel
- +1-832-696-8203
- Fax
- +1-832-641-3177
- info@apexbt.com
- Country
- United States
- ProdList
- 477
- Advantage
- 60
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4817
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 86249
- Advantage
- 60
- Tel
- 13761635123
- Fax
- 1014988033@qq
- sales@linyuepharm.com
- Country
- China
- ProdList
- 5562
- Advantage
- 55
- Tel
- 微信 17321281695 18019252918
- Fax
- qq:1454668768
- 1454668768@qq.com
- Country
- China
- ProdList
- 14942
- Advantage
- 58
- Tel
- 17625585511
- Fax
- qq：1580084073
- 1580084073@qq.com
- Country
- China
- ProdList
- 996
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24960
- Advantage
- 58