5-(TrifluoroMethyl)benzoxazole

Product Name: 5-(TrifluoroMethyl)benzoxazole
CAS No.: 1267217-46-8
Chemical Name: 5-(TrifluoroMethyl)benzoxazole
Synonyms: 5-(TrifluoroMethyl)benzoxazole;Benzoxazole, 5-(trifluoromethyl)-;5-(TrifluoroMethyl)benzo[d]oxazole;5-(trifluoromethyl)-1,3-benzoxazole;5-(Trifluoromethyl)-1,3-benzoxazole95%;5-(Trifluoromethyl)-1,3-benzoxazole 95%
CBNumber: CB32596944
Molecular Formula: C8H4F3NO
Formula Weight: 187.12
MOL File: 1267217-46-8.mol

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5-(TrifluoroMethyl)benzoxazole Property

Melting point:: 43-44 °C(Solv: hexane (110-54-3))
Boiling point:: 195.6±35.0 °C(Predicted)
Density: 1.406±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -3.31±0.10(Predicted)
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T897655
Product name: 5-(Trifluoromethyl)benzoxazole
Packaging: 100mg
Price: $65
Updated: 2021/12/16

TRC

Product number: T897655
Product name: 5-(Trifluoromethyl)benzoxazole
Packaging: 500mg
Price: $240
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-3-N1
Product name: 5-(Trifluoromethyl)-1,3-benzoxazole
Purity: 95%
Packaging: 1g
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: 5268AA
Product name: 5-(Trifluoromethyl)benzo[d]oxazole
Packaging: 1g
Price: $265
Updated: 2021/12/16

Apolloscientific

Product number: PC300509
Product name: 5-(Trifluoromethyl)-1,3-benzoxazole
Purity: 95%
Packaging: 5g
Price: $350
Updated: 2021/12/16

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5-(TrifluoroMethyl)benzoxazole Chemical Properties,Usage,Production

Synthesis

400-99-7

122-51-0

1267217-46-8

The general procedure for the synthesis of 5-trifluoromethylbenzoxazole from 2-nitro-4-trifluoromethylphenol and triethyl orthoformate was as follows: 2-nitro-4-(trifluoromethyl)phenol (500 mg, 2.41 mmol) and a palladium/carbon catalyst (200 mg) were added to ethanol (10 ml) at 0 °C and under argon protection. After hydrogen was passed to replace the air in the reaction system, the reaction was stirred at room temperature overnight. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure. To the concentrated residue, triethyl orthoformate (2.4 ml, 14.5 mmol) was added and p-toluenesulfonic acid monohydrate (23 mg, 0.12 mmol) was added dropwise as a catalyst. The reaction mixture was heated to reflux and stirred for 3 hours under argon protection. Upon completion of the reaction, the reaction solution was concentrated to dryness. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to give 5-trifluoromethylbenzoxazole (182 mg, 40% yield).

References

[1] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0108

5-(TrifluoroMethyl)benzoxazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1267217-46-8