2,4,6-trichloronicotinaldehyde

Product Name: 2,4,6-trichloronicotinaldehyde
CAS No.: 1261269-66-2
Chemical Name: 2,4,6-trichloronicotinaldehyde
Synonyms: 2,4,6-trichloronicotinaldehyde;2,4,6-trichloropyridine-3-carbaldehyde;2,4,6-Trichloropyridine-3-carboxaldehyde;3-Pyridinecarboxaldehyde, 2,4,6-trichloro-
CBNumber: CB32597901
Molecular Formula: C6H2Cl3NO
Formula Weight: 210.45
MOL File: 1261269-66-2.mol

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2,4,6-trichloronicotinaldehyde Property

Boiling point:: 297.5±35.0 °C(Predicted)
Density: 1.616±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -4.22±0.10(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C6H2Cl3NO/c7-4-1-5(8)10-6(9)3(4)2-11/h1-2H
InChIKey: RESMQRUOHBZJCA-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=CC(Cl)=C1C=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: T897660
Product name: 2,4,6-Trichloronicotinaldehyde
Packaging: 100mg
Price: $175
Updated: 2021/12/16

AK Scientific

Product number: 7783BB
Product name: 2,4,6-Trichloronicotinaldehyde
Packaging: 250mg
Price: $216
Updated: 2021/12/16

AK Scientific

Product number: 7783BB
Product name: 2,4,6-Trichloronicotinaldehyde
Packaging: 1g
Price: $435
Updated: 2021/12/16

ChemScene

Product number: CS-0047127
Product name: 2,4,6-Trichloronicotinaldehyde
Packaging: 1g
Price: $455
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0362623
Product name: 2,4,6-TRICHLORONICOTINALDEHYDE
Purity: 95.00%
Packaging: 5MG
Price: $495.28
Updated: 2021/12/16

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2,4,6-trichloronicotinaldehyde Chemical Properties,Usage,Production

Synthesis

16063-69-7

109-94-4

1261269-66-2

GENERAL STEPS: 2,4,6-Trichloropyridine (5 g, 27.4 mmol) was dissolved in anhydrous THF (100 ml) and the solution was cooled to -78 °C. N-butyllithium (22.27 ml, 28.8 mmol, 1.6 M hexane solution) was slowly added at -78 °C and stirred for 30 min. Subsequently, ethyl formate (10.15 g, 137 mmol) was added, ensuring that the internal temperature was maintained below -74 °C. The reaction mixture was stirred continuously at -78 °C until the feedstock was completely consumed (9:1 unfolding agent ratio of heptane/EtOAc monitored by TLC). Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution (50 ml) and 0.5 N HCl solution at -78 °C. The mixture was warmed to room temperature and extracted with EtOAc. The organic phase was washed with brine, dried over MgSO4 and concentrated. The crude product (light yellow solid) was purified by rapid chromatography on silica gel with 0-20% EtOAc/heptane as eluent to give 5.1 g (88% yield) of the target product 2,4,6-trichloronicotinaldehyde as a white solid.1H NMR (400 MHz, chloroform-d3) δppm= 10.42 (s, 1H), 7.45 (s, 1H).

References

[1] Patent: US2018/111932, 2018, A1. Location in patent: Paragraph 0388; 0389
[2] Patent: US2015/57260, 2015, A1. Location in patent: Paragraph 0765; 0766; 1088; 1089
[3] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 178; 179
[4] Patent: WO2015/25025, 2015, A1. Location in patent: Page/Page column 399

2,4,6-trichloronicotinaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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1261269-66-2, 2,4,6-trichloronicotinaldehydeRelated Search:

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2,4,6-trichloronicotinaldehyde

2,4,6-trichloropyridine-3-carbaldehyde

3-Pyridinecarboxaldehyde, 2,4,6-trichloro-

2,4,6-Trichloropyridine-3-carboxaldehyde

1261269-66-2