2,4,6-trichloronicotinaldehyde
- Product Name
- 2,4,6-trichloronicotinaldehyde
- CAS No.
- 1261269-66-2
- Chemical Name
- 2,4,6-trichloronicotinaldehyde
- Synonyms
- 2,4,6-trichloronicotinaldehyde;2,4,6-trichloropyridine-3-carbaldehyde;2,4,6-Trichloropyridine-3-carboxaldehyde;3-Pyridinecarboxaldehyde, 2,4,6-trichloro-
- CBNumber
- CB32597901
- Molecular Formula
- C6H2Cl3NO
- Formula Weight
- 210.45
- MOL File
- 1261269-66-2.mol
2,4,6-trichloronicotinaldehyde Property
- Boiling point:
- 297.5±35.0 °C(Predicted)
- Density
- 1.616±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -4.22±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C6H2Cl3NO/c7-4-1-5(8)10-6(9)3(4)2-11/h1-2H
- InChIKey
- RESMQRUOHBZJCA-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC(Cl)=C1C=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- T897660
- Product name
- 2,4,6-Trichloronicotinaldehyde
- Packaging
- 100mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 7783BB
- Product name
- 2,4,6-Trichloronicotinaldehyde
- Packaging
- 250mg
- Price
- $216
- Updated
- 2021/12/16
- Product number
- 7783BB
- Product name
- 2,4,6-Trichloronicotinaldehyde
- Packaging
- 1g
- Price
- $435
- Updated
- 2021/12/16
- Product number
- CS-0047127
- Product name
- 2,4,6-Trichloronicotinaldehyde
- Packaging
- 1g
- Price
- $455
- Updated
- 2021/12/16
- Product number
- HCH0362623
- Product name
- 2,4,6-TRICHLORONICOTINALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.28
- Updated
- 2021/12/16
2,4,6-trichloronicotinaldehyde Chemical Properties,Usage,Production
Synthesis
16063-69-7
109-94-4
1261269-66-2
GENERAL STEPS: 2,4,6-Trichloropyridine (5 g, 27.4 mmol) was dissolved in anhydrous THF (100 ml) and the solution was cooled to -78 °C. N-butyllithium (22.27 ml, 28.8 mmol, 1.6 M hexane solution) was slowly added at -78 °C and stirred for 30 min. Subsequently, ethyl formate (10.15 g, 137 mmol) was added, ensuring that the internal temperature was maintained below -74 °C. The reaction mixture was stirred continuously at -78 °C until the feedstock was completely consumed (9:1 unfolding agent ratio of heptane/EtOAc monitored by TLC). Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution (50 ml) and 0.5 N HCl solution at -78 °C. The mixture was warmed to room temperature and extracted with EtOAc. The organic phase was washed with brine, dried over MgSO4 and concentrated. The crude product (light yellow solid) was purified by rapid chromatography on silica gel with 0-20% EtOAc/heptane as eluent to give 5.1 g (88% yield) of the target product 2,4,6-trichloronicotinaldehyde as a white solid.1H NMR (400 MHz, chloroform-d3) δppm= 10.42 (s, 1H), 7.45 (s, 1H).
References
[1] Patent: US2018/111932, 2018, A1. Location in patent: Paragraph 0388; 0389
[2] Patent: US2015/57260, 2015, A1. Location in patent: Paragraph 0765; 0766; 1088; 1089
[3] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 178; 179
[4] Patent: WO2015/25025, 2015, A1. Location in patent: Page/Page column 399
2,4,6-trichloronicotinaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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