ChemicalBook > CAS DataBase List > TPPB

TPPB

Product Name
TPPB
CAS No.
497259-23-1
Chemical Name
TPPB
Synonyms
TPPB;CS-2585;TPPB, 10 mM in DMSO;α-Amyloid Precursor Protein Modulator;alpha-AMyloid Precursor Protein Modulator;PKC,Protein kinase C,TPPB,inhibit,Inhibitor;α-Amyloid Precursor Protein Modulator(TPPB);α-Amyloid Precursor Protein Modulator, >=98%;TPPB/ α-Amyloid Precursor Protein Modulator;(2E,4E)-N-[(2S,5R)-5-(hydroxymethyl)-1-methyl-3-oxo-2-(propan-2-yl)-1,2,3,4,5,6-hexahydro-1-benzazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide
CBNumber
CB32602544
Molecular Formula
C27H30F3N3O3
Formula Weight
501.54
MOL File
497259-23-1.mol
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TPPB Property

Boiling point:
728.8±60.0 °C(Predicted)
Density 
1.229
storage temp. 
Store at -20°C
solubility 
25.08mg/mL in DMSO
pka
12.76±0.60(Predicted)
form 
Solid
color 
Light yellow to yellow
InChIKey
WOLVEMPZUIFSII-IHHOKICGSA-N
SMILES
C(NC1=CC=C2N(C)[C@@H](C(C)C)C(=O)N[C@H](CO)CC2=C1)(=O)/C=C/C=C/C1=CC=C(C(F)(F)F)C=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
565740
Product name
α-Amyloid Precursor Protein Modulator
Purity
A cell-permeable benzolactam derived PKC activator (K<sub>i</sub> = 11.9 nM for PKC&#945;) that efficiently enhances non-amyloidogenic &#945;-processing of amyloid precursor protein (APP) even at 100
Packaging
1 mg
Price
$359
Updated
2025/07/31
Tocris
Product number
5343
Product name
TPPB
Purity
≥98%(HPLC)
Packaging
1
Price
$145
Updated
2021/12/16
TRC
Product number
T700578
Product name
TPPB
Packaging
1mg
Price
$285
Updated
2021/12/16
TRC
Product number
T700578
Product name
TPPB
Packaging
2.5mg
Price
$615
Updated
2021/12/16
ChemScene
Product number
CS-7939
Product name
TPPB
Purity
99.81%
Packaging
5mg
Price
$800
Updated
2021/12/16
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TPPB Chemical Properties,Usage,Production

Uses

TPPB is a protein kinase C (PKC) activator.

Biological Activity

Cell permeable: yes', 'Primary Target
PKC', 'Product does not compete with ATP.', 'Reversible: no', 'Target Ki: 11.9 nM for activating PKCα

storage

Store at -20°C

TPPB Preparation Products And Raw materials

Raw materials

Preparation Products

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TPPB Suppliers

China 82 United Kingdom 1 United States 13 Global 96
Changsha Fuzhen Biotechnology Co.，LTD
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View Lastest Price from TPPB manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
TPPB 497259-23-1
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-17

497259-23-1, TPPBRelated Search:


  • TPPB
  • (2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide
  • alpha-AMyloid Precursor Protein Modulator
  • TPPB/ α-Amyloid Precursor Protein Modulator
  • α-Amyloid Precursor Protein Modulator, >=98%
  • (2E,4E)-N-((2S,5S)-5-(hydroxymethyl)-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydrobenzo[e][1,4]diazocin-8-yl)-5-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide
  • (2E,4E)-N-[(2S,5R)-5-(hydroxymethyl)-1-methyl-3-oxo-2-(propan-2-yl)-1,2,3,4,5,6-hexahydro-1-benzazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide
  • CS-2585
  • 2,4-Pentadienamide, N-[(2S,5S)-1,2,3,4,5,6-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-, (2E,4E)-
  • α-Amyloid Precursor Protein Modulator
  • PKC,Protein kinase C,TPPB,inhibit,Inhibitor
  • (2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide
  • α-Amyloid Precursor Protein Modulator(TPPB)
  • (2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-(propan-2-yl)-1,2,3,4,5,6-hexahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide
  • TPPB, 10 mM in DMSO
  • 497259-23-1
  • C27H30F3N3O3
  • C28H31F3N2O3
  • API