ChemicalBook > CAS DataBase List > TC-N 1752

TC-N 1752

Product Name
TC-N 1752
CAS No.
1211866-85-1
Chemical Name
TC-N 1752
Synonyms
TC-N 1752;TC-N 1752-d5;Nav1.7 blocker 52;TCN 1752,TC N 1752;TC-N 1752, 10 mM in DMSO;N-(2-Methyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)phenyl)acetamide;N-[2-METHYL-3-[[4-[4-[[4-(TRIFLUOROMETHOXY)PHENYL]METHOXY]-1-PIPERIDINYL]-1,3,5-TRIAZIN-2-YL]AMINO]PHENYL]ACETAMIDE;AcetaMide, N-[2-Methyl-3-[[4-[4-[[4-(trifluoroMethoxy)phenyl]Methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]aMino]phenyl]-
CBNumber
CB32603006
Molecular Formula
C25H27F3N6O3
Formula Weight
516.52
MOL File
1211866-85-1.mol
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TC-N 1752 Property

Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl
form 
Powder
pka
14.80±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4435
Product name
TC-N1752
Purity
≥99%(HPLC)
Packaging
10
Price
$261
Updated
2021/12/16
Tocris
Product number
4435
Product name
TC-N1752
Purity
≥99%(HPLC)
Packaging
50
Price
$1040
Updated
2021/12/16
TRC
Product number
T126035
Product name
TC-N1752
Packaging
10mg
Price
$240
Updated
2021/12/16
Usbiological
Product number
256851
Product name
TC-N 1752
Packaging
10mg
Price
$516
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001547
Product name
TCN-1752
Purity
99.00%
Packaging
5MG
Price
$532
Updated
2021/12/16
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TC-N 1752 Chemical Properties,Usage,Production

Uses

TC-N 1752 is a potent, state-dependent inhibitor of Nav1.7, which is a neuronal voltage gated sodium channel and a critical mediator of pain sensitization.

in vivo

TC-N 1752 (compound 52) (3-30 mg/kg; p.o.) dose-dependently shows analgesic effect in the Formalin model[1].
TC-N 1752 (3-30 mg/kg; p.o.) decreases thermal hyperalgesia produced by inflammation[3].
TC-N 1752 (5 mg/mL; 500 μL; i.v.) attenuates complete Freund’s adjuvant (CFA)-induced sensitization of C-fiber nociceptors[3].

Animal Model:Rats were injected intraplantar with Formalin[1]
Dosage:3, 10, 20, 30 mg/kg
Administration:Administered p.o. 120 min prior to Formalin
Result:Showed analgesic efficacy starting at the dose of 3 mg/kg, with full efficacy at 20 mg/kg dose.

IC 50

hNav1.7: 0.17 μM (IC50); hNav1.8: 0.1 μM (IC50); hNav1.3: 0.3 μM (IC50); hNav1.4: 0.4 μM (IC50); hNav1.5: 1.1 μM (IC50)

storage

+4°C

TC-N 1752 Preparation Products And Raw materials

Raw materials

Preparation Products

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TC-N 1752 Suppliers

China 29 United Kingdom 1 United States 6 USA 1 Global 37
Bide Pharmatech Ltd.
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Nanjing Shizhou Biology Technology Co.,Ltd
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Nanjing Shizhou Biology Technology Co.,Ltd
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TargetMol Chemicals Inc.
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Nantong QuanYi Biotechnology Co., Ltd
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RD International Technology Co., Limited
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Cayman Chemical Company
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ATK CHEMICAL COMPANY LIMITED
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1211866-85-1, TC-N 1752Related Search:


  • TC-N 1752
  • AcetaMide, N-[2-Methyl-3-[[4-[4-[[4-(trifluoroMethoxy)phenyl]Methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]aMino]phenyl]-
  • Nav1.7 blocker 52
  • N-[2-METHYL-3-[[4-[4-[[4-(TRIFLUOROMETHOXY)PHENYL]METHOXY]-1-PIPERIDINYL]-1,3,5-TRIAZIN-2-YL]AMINO]PHENYL]ACETAMIDE
  • TC-N 1752-d5
  • TCN 1752,TC N 1752
  • TC-N 1752, 10 mM in DMSO
  • N-(2-Methyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)phenyl)acetamide
  • 1211866-85-1
  • C25H27F3N6O3