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Belinostat (PXD101)

Product Name
Belinostat (PXD101)
CAS No.
414864-00-9
Chemical Name
Belinostat (PXD101)
Synonyms
Belinostat;PXD101;CS-424;PX105684;NSC726630;belinosta;BelioMstat;BENLINOSTAT;Belinostat-D5;Rac-Belinostat
CBNumber
CB3260643
Molecular Formula
C15H14N2O4S
Formula Weight
318.35
MOL File
414864-00-9.mol
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Belinostat (PXD101) Property

Melting point:
142 - 145°C
Density 
1.427±0.06 g/cm3(Predicted)
storage temp. 
Amber Vial, Refrigerator, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
8.31±0.10(Predicted)
color 
Off-White to Pale Orange
Stability:
Light Sensitive
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Safety

HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B131400
Product name
Belinostat(PXD-101)
Packaging
10mg
Price
$150
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611512
Product name
Belinostat
Packaging
1g
Price
$912.9
Updated
2021/12/16
Biorbyt Ltd
Product number
orb180941
Product name
Belinostat (PXD101)
Purity
>98%
Packaging
1g
Price
$1208.7
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003555
Product name
BELINOSTAT
Purity
95.00%
Packaging
1G
Price
$1526.7
Updated
2021/12/16
Matrix Scientific
Product number
143757
Product name
(E)-N-Hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide
Purity
95%
Packaging
1g
Price
$1850
Updated
2021/12/16
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Belinostat (PXD101) Chemical Properties,Usage,Production

Description

Belinostat is a drug which was developed by Spectrum Pharmaceuticals and is currently marketed by Onxeo as Beleodaq®. The drug, which received fast track designation by the United States Food and Drug Administration (US FDA) and was approved for the treatment of hematological malignancies and solid tumors associated with peripheral T-cell lymphoma (PTCL) in 2014, is a histone deacetylase (HDAC) inhibitor and is the third such treatment to receive accelerated approval for PTCL, the others being vorinostat (Zolinza®) and pralatrexate (Folotyn®). Although belinostat was not yet approved in Europe as of August 2014, the compound exhibits a safety profile considered to be acceptable for HDAC inhibitors–less than 25% of patients reported adverse effects and these most frequently were nausea, fatigue, pyrexia, anemia, and emesis.

Uses

Belinostat is a novel histone deacetylase 3 selective inhibitor, which protects the β cells from cytokine-induced apoptosis.

Definition

ChEBI: A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.

Synthesis

Commercially available 3-bromobenzenesulfonyl chloride (41) was reacted with aniline in the presence of aqueous sodium carbonate to deliver sulfonamide 42 in 94% yield. Next, this aryl bromide was subjected to a Heck reaction involving ethyl acrylate to give rise to cinnamate ester 43, which was immediately saponified under basic conditions and acidic workup to furnish the corresponding acid 44. This acid was activated as the corresponding acid chloride prior to subjection to hydroxylamine under basic conditions to form the hydroxamic acid, which was then recrystallized from an 8:1 ethanol/water mixture in the presence of a catalytic amount of sodium bicarbonate to furnish crystalline belinostat (VI) in 87% overall yield from acid 44.

target

pan-HDAC

Belinostat (PXD101) Preparation Products And Raw materials

Raw materials

Preparation Products

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Belinostat (PXD101) Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
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61
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
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62
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4554
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Chengdu Forest Science and Technology Development Co., Ltd.
Tel
18030648795 18030648795
Fax
028-61777050
Email
sales@cdforestchem.com
Country
China
ProdList
1997
Advantage
58
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
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View Lastest Price from Belinostat (PXD101) manufacturers

Career Henan Chemical Co
Product
Belinostat (PXD101) 414864-00-9
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-21

414864-00-9, Belinostat (PXD101)Related Search:


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