4-Bromo-1H-indole-7-carboxylic acid
- Product Name
- 4-Bromo-1H-indole-7-carboxylic acid
- CAS No.
- 1211594-25-0
- Chemical Name
- 4-Bromo-1H-indole-7-carboxylic acid
- Synonyms
- 4-Bromoindole-7-carboxylic Acid;4-broMo-1H-indole-7-carboxylic acid;1H-Indole-7-carboxylic acid, 4-broMo-
- CBNumber
- CB32607064
- Molecular Formula
- C9H6BrNO2
- Formula Weight
- 240.05
- MOL File
- 1211594-25-0.mol
4-Bromo-1H-indole-7-carboxylic acid Property
- Boiling point:
- 455.8±30.0 °C(Predicted)
- Density
- 1.838±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.54±0.10(Predicted)
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C9H6BrNO2/c10-7-2-1-6(9(12)13)8-5(7)3-4-11-8/h1-4,11H,(H,12,13)
- InChIKey
- CDTILRQKJWYBOM-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(Br)=CC=C2C(O)=O)C=C1
N-Bromosuccinimide Price
- Product number
- B998015
- Product name
- 4-Bromo-1H-indole-7-carboxylicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0365508
- Product name
- 4-BROMO-1H-INDOLE-7-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.64
- Updated
- 2021/12/16
- Product number
- CM147931
- Product name
- 4-Bromo-1H-indole-7-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- 1211594250
- Product name
- 4-Bromo-1H-indole-7-carboxylicacid
- Packaging
- 1g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- SC-26955
- Product name
- 4-BROMO-1H-INDOLE-7-CARBOXYLIC ACID
- Purity
- 95+%
- Packaging
- 1g
- Price
- $750
- Updated
- 2021/12/16
4-Bromo-1H-indole-7-carboxylic acid Chemical Properties,Usage,Production
Synthesis
1224724-39-3
1211594-25-0
To a solution of methyl 4-bromo-1H-indole-7-carboxylate (6 g, 23 mmol, Preparation 1 Step B) in tetrahydrofuran (THF, 300 mL) was added water (60 mL), methanol (MeOH, 60 mL) and lithium hydroxide (2.83 g, 118 mmol). The reaction mixture was heated to reflux and stirred overnight. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove the solvent. To the remaining aqueous layer 4N hydrochloric acid (HCl) was slowly added to adjust the pH to about 6. The precipitate precipitated was collected by filtration and the solid was dried to give 4-bromo-1H-indole-7-carboxylic acid (5.5 g, 97% yield). The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 11.39 (br, 1H), 7.65-7.63 (d, J = 8.0 Hz, 1H), 7.46-7.44 (m, 1H), 7.33-7.31 (d, J = 8.0 Hz, 1H), 6.49-6.48 (m, 1H).
References
[1] Patent: WO2014/210255, 2014, A1. Location in patent: Page/Page column 101
4-Bromo-1H-indole-7-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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