ChemicalBook > CAS DataBase List > 3-Pyridinecarboxylic acid, 5-chloro-2-Methyl-, ethyl ester

3-Pyridinecarboxylic acid, 5-chloro-2-Methyl-, ethyl ester

Product Name: 3-Pyridinecarboxylic acid, 5-chloro-2-Methyl-, ethyl ester
CAS No.: 868636-76-4
Chemical Name: 3-Pyridinecarboxylic acid, 5-chloro-2-Methyl-, ethyl ester
Synonyms: ethyl 5-chloro-2-Methylnicotinate;3-Pyridinecarboxylic acid, 5-chloro-2-Methyl-, ethyl ester
CBNumber: CB32609846
Molecular Formula: C9H10ClNO2
Formula Weight: 199.63
MOL File: 868636-76-4.mol

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3-Pyridinecarboxylic acid, 5-chloro-2-Methyl-, ethyl ester Property

Boiling point:: 251.8±35.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 1.74±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 3662AC
Product name: Ethyl5-chloro-2-methylnicotinate
Packaging: 250mg
Price: $180
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0368952
Product name: ETHYL-5-CHLORO-2-METHYLNICOTINATE
Purity: 95.00%
Packaging: 250MG
Price: $342.3
Updated: 2021/12/16

AK Scientific

Product number: 3662AC
Product name: Ethyl5-chloro-2-methylnicotinate
Packaging: 5g
Price: $1022
Updated: 2021/12/16

Chemenu

Product number: CM124097
Product name: ethyl5-chloro-2-methylnicotinate
Purity: 95%
Packaging: 5g
Price: $673
Updated: 2021/12/16

Crysdot

Product number: CD11040628
Product name: Ethyl5-chloro-2-methylnicotinate
Purity: 95+%
Packaging: 5g
Price: $713
Updated: 2021/12/16

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3-Pyridinecarboxylic acid, 5-chloro-2-Methyl-, ethyl ester Chemical Properties,Usage,Production

Synthesis

823-96-1

148065-10-5

868636-76-4

Step 2. Synthesis of ethyl 5-chloro-2-methylnicotinate: Under nitrogen protection, a mixture of ethyl 2,5-dichloronicotinate (10 g, 0.045 mol), tetrakis(triphenylphosphine)palladium (5.2 g, 4.5 mmol), trimethylcycloboroxane (5.65 g, 0.045 mol), and potassium carbonate (18.66 g, 0.16 mol) was dissolved in 1,4- dioxane (containing 10% water, 100 ml) and the reaction was refluxed for 7 hours. After completion of the reaction, the mixture was cooled to room temperature, poured into water and the aqueous phase was extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography on silica gel with hexane/ethyl acetate (50/1 to 20/1) as eluent to give 3.41 g of ethyl 5-chloro-2-methylnicotinate in 38% yield. The product was characterized by 1H-NMR (CDCl3): δ 8.57 (1H, d, J = 2.5 Hz), 8.17 (1H, d, J = 2.5 Hz), 4.39 (2H, dd, J = 7.1, 14.2 Hz), 2.81 (3H, s), 1.41 (3H, t, J = 7.1 Hz).

References

[1] Patent: WO2005/105732, 2005, A1. Location in patent: Page/Page column 59
[2] Patent: WO2005/102389, 2005, A2. Location in patent: Page/Page column 208

3-Pyridinecarboxylic acid, 5-chloro-2-Methyl-, ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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