ethyl 5-aMino-2,6-dichloropyriMidine-4-carboxylate
- Product Name
- ethyl 5-aMino-2,6-dichloropyriMidine-4-carboxylate
- CAS No.
- 54368-62-6
- Chemical Name
- ethyl 5-aMino-2,6-dichloropyriMidine-4-carboxylate
- Synonyms
- ethyl 5-aMino-2,6-dichloropyriMidine-4-carboxylate;5-Amino-2,6-dichloro-4-pyrimidinecarboxylic acid ethyl ester;5-AMino-2,6-dichloro-pyriMidine-4-carboxylic acid ethyl ester;4-Pyrimidinecarboxylic acid, 5-amino-2,6-dichloro-, ethyl ester
- CBNumber
- CB32610336
- Molecular Formula
- C7H7Cl2N3O2
- Formula Weight
- 236.06
- MOL File
- 54368-62-6.mol
ethyl 5-aMino-2,6-dichloropyriMidine-4-carboxylate Property
- Boiling point:
- 358.0±37.0 °C(Predicted)
- Density
- 1.508±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -4.07±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C7H7Cl2N3O2/c1-2-14-6(13)4-3(10)5(8)12-7(9)11-4/h2,10H2,1H3
- InChIKey
- CAUKXOUUXPKJQC-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=C(N)C(C(OCC)=O)=N1
N-Bromosuccinimide Price
- Product number
- E899488
- Product name
- Ethyl5-amino-2,6-dichloropyrimidine-4-carboxylate
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- E899488
- Product name
- Ethyl5-amino-2,6-dichloropyrimidine-4-carboxylate
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 126633
- Product name
- Ethyl5-amino-2,6-dichloropyrimidine-4-carboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $1710
- Updated
- 2021/12/16
- Product number
- HCH0368911
- Product name
- ETHYL-5-AMINO-2,6-DICHLOROPYRIMIDINE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $253.05
- Updated
- 2021/12/16
- Product number
- Z4859
- Product name
- Ethyl5-amino-2,6-dichloropyrimidine-4-carboxylate
- Packaging
- 5g
- Price
- $548
- Updated
- 2021/12/16
ethyl 5-aMino-2,6-dichloropyriMidine-4-carboxylate Chemical Properties,Usage,Production
Synthesis
54368-61-5
54368-62-6
Ethyl 2,6-dichloro-5-nitropyrimidine-4-carboxylate (1 g, 3.76 mmol, 1.00 eq.) was used as starting material to form a suspension with stannous chloride dihydrate (3.38 g, 14.98 mmol, 1.00 eq.) in ethyl acetate (30 mL). The mixture was transferred to a 50 mL sealed tube and the reaction was stirred at 70 °C for 5 hours. Upon completion of the reaction, the resulting solution was diluted with 50 mL of water and the pH was adjusted with sodium carbonate to 9. Subsequently, extraction was carried out with ethyl acetate (3 x 100 mL), and the organic phases were combined, washed sequentially with water and brine, and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting residue was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1:5) to afford the target product ethyl 5-amino-2,6-dichloro-4-pyrimidinecarboxylate (572 mg, 64% yield) as a light yellow solid.LC-MS (ES, m/z): 236 [M + H]+.
References
[1] Patent: US2015/57260, 2015, A1. Location in patent: Paragraph 0743; 0744; 1003; 1004
[2] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 174
ethyl 5-aMino-2,6-dichloropyriMidine-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl 5-aMino-2,6-dichloropyriMidine-4-carboxylate Suppliers
- Tel
- 025-85767923 18512596075
- Fax
- 025-85767923
- sales@nuoxibio.com
- Country
- China
- ProdList
- 996
- Advantage
- 55
- Tel
- +86-21-68182121
- Fax
- +86-21-68182121
- Country
- China
- ProdList
- 882
- Advantage
- 52
- Tel
- 13761987713
- Fax
- 021 51613951
- hxzheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8667
- Advantage
- 57
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 18957373295
- Fax
- -
- Country
- China
- ProdList
- 1580
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 14995
- Advantage
- 55
- Tel
- 13260807071
- Fax
- -
- gzd520112@163.com
- Country
- China
- ProdList
- 90
- Advantage
- 55
- Tel
- 025-57027729 15850702895
- Fax
- 025-57027729
- 15850702895@163.com
- Country
- China
- ProdList
- 88
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
View Lastest Price from ethyl 5-aMino-2,6-dichloropyriMidine-4-carboxylate manufacturers
- Product
- ethyl 5-aMino-2,6-dichloropyriMidine-4-carboxylate 54368-62-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22