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Apatinib Mesylate

Product Name
Apatinib Mesylate
CAS No.
1218779-75-9
Chemical Name
Apatinib Mesylate
Synonyms
Apatinib Mesylate;YN 968D1;Rivoceranib (Apatinib);Apatinib methanesulfonate;Apatinib Mesylate(YN968D1);Apatinib (YN968D1) mesylate;Protein Tyrosine Kinase Inhibitors;Pyrazino[2,3-f][1,14]phenanthroline;N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-methylpyridin-3-yl)amino]pyridine-3-carboxamide;N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide methanesulfonate
CBNumber
CB32614349
Molecular Formula
C25H27N5O4S
Formula Weight
493.58
MOL File
1218779-75-9.mol
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Apatinib Mesylate Property

storage temp. 
Store at -20°C
solubility 
≥49.4 mg/mL in DMSO; insoluble in H2O; ≥2.17 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
Water Solubility 
Water: Insoluble
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FA145494
Product name
Apatinib mesylate
Packaging
10mg
Price
$100
Updated
2021/12/16
ApexBio Technology
Product number
B2303
Product name
Apatinib
Packaging
5mg
Price
$128
Updated
2021/12/16
ApexBio Technology
Product number
B2303
Product name
Apatinib
Packaging
10mM(in 1mL DMSO)
Price
$130
Updated
2021/12/16
ApexBio Technology
Product number
B2303
Product name
Apatinib
Packaging
10mg
Price
$143
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA145494
Product name
Apatinib mesylate
Packaging
25mg
Price
$200
Updated
2021/12/16
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Apatinib Mesylate Chemical Properties,Usage,Production

Biological Activity

apatinib (yn968d1)is a potent inhibior of the vegf signaling pathway with the ic50 value of 1nm for vegfr-2 in in vitro enzyme experiments [1]..

in vitro

apatinib has shown the inhibition of tyrosine kinase activities with the ic50 values of 0.013μm, 0.429μm and 0.53μm for ret, c-kit and c-src, respectively. in addition, apatinib has been revealed to have no significant effects in egfr, her-2 or fgfr1 in concentrations up to 10μm. apart from these, apatinib has been reported to inhibit the growth factor-stimulated receptor phosphorylation at the cellular level. furthermore, apatinib has also reported to slightly inhibitor proliferation of huvec by 20% fbs with the ic50 value of 23.4μm and significantly inhibit stimulated by 20ng/ml vegf with the ic50 value of 0.17μm. once-daily oral administration of apatinib has been noted to produce a dose-dependent inhibition of tumor growth in human tumor xenografts in immunodeficient mice [1]

References

[1] tian s1, quan h, xie c, guo h, lü f, xu y, li j, lou l. yn968d1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. cancer sci. 2011 jul;102(7):1374-80.

Apatinib Mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Apatinib Mesylate Suppliers

Nantong Hanfang Biotechnology Co. , Ltd.
Tel
18616537568
Email
hanfangpharma@126.com
Country
China
ProdList
29971
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19179
Advantage
64
ChemShuttle, Inc.
Tel
0510-83588313-802 18800520310;
Email
sales@chemshuttle.com
Country
China
ProdList
3002
Advantage
62
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
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View Lastest Price from Apatinib Mesylate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Apatinib mesylate 1218779-75-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%+
Supply Ability
100 tons
Release date
2019-12-31
Career Henan Chemical Co
Product
N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide methanesulfonate 1218779-75-9
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

1218779-75-9, Apatinib MesylateRelated Search:


  • Apatinib Mesylate(YN968D1)
  • Apatinib methanesulfonate
  • N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide methanesulfonic acid
  • N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide methanesulfonate
  • YN 968D1
  • N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide methanesulfonate ISO 9001:2015 REACH
  • Pyrazino[2,3-f][1,14]phenanthroline
  • Apatinib Mesylate
  • N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide methanesulfonate
  • Apatinib (YN968D1) mesylate
  • N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-methylpyridin-3-yl)amino]pyridine-3-carboxamide
  • Rivoceranib (Apatinib)
  • Protein Tyrosine Kinase Inhibitors
  • 1218779-75-9
  • C24H23N5OCH4O3S