Apatinib Mesylate
- Product Name
- Apatinib Mesylate
- CAS No.
- 1218779-75-9
- Chemical Name
- Apatinib Mesylate
- Synonyms
- Apatinib Mesylate;YN 968D1;Rivoceranib (Apatinib);Apatinib methanesulfonate;Apatinib Mesylate(YN968D1);Apatinib (YN968D1) mesylate;Protein Tyrosine Kinase Inhibitors;Pyrazino[2,3-f][1,14]phenanthroline;N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-methylpyridin-3-yl)amino]pyridine-3-carboxamide;N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide methanesulfonate
- CBNumber
- CB32614349
- Molecular Formula
- C25H27N5O4S
- Formula Weight
- 493.58
- MOL File
- 1218779-75-9.mol
Apatinib Mesylate Property
- storage temp.
- Store at -20°C
- solubility
- ≥49.4 mg/mL in DMSO; insoluble in H2O; ≥2.17 mg/mL in EtOH with gentle warming and ultrasonic
- form
- solid
- Water Solubility
- Water: Insoluble
N-Bromosuccinimide Price
- Product number
- FA145494
- Product name
- Apatinib mesylate
- Packaging
- 10mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- B2303
- Product name
- Apatinib
- Packaging
- 5mg
- Price
- $128
- Updated
- 2021/12/16
- Product number
- B2303
- Product name
- Apatinib
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B2303
- Product name
- Apatinib
- Packaging
- 10mg
- Price
- $143
- Updated
- 2021/12/16
- Product number
- FA145494
- Product name
- Apatinib mesylate
- Packaging
- 25mg
- Price
- $200
- Updated
- 2021/12/16
Apatinib Mesylate Chemical Properties,Usage,Production
Biological Activity
apatinib （yn968d1）is a potent inhibior of the vegf signaling pathway with the ic50 value of 1nm for vegfr-2 in in vitro enzyme experiments [1]..
in vitro
apatinib has shown the inhibition of tyrosine kinase activities with the ic50 values of 0.013μm, 0.429μm and 0.53μm for ret, c-kit and c-src, respectively. in addition, apatinib has been revealed to have no significant effects in egfr, her-2 or fgfr1 in concentrations up to 10μm. apart from these, apatinib has been reported to inhibit the growth factor-stimulated receptor phosphorylation at the cellular level. furthermore, apatinib has also reported to slightly inhibitor proliferation of huvec by 20% fbs with the ic50 value of 23.4μm and significantly inhibit stimulated by 20ng/ml vegf with the ic50 value of 0.17μm. once-daily oral administration of apatinib has been noted to produce a dose-dependent inhibition of tumor growth in human tumor xenografts in immunodeficient mice [1]
References
[1] tian s1, quan h, xie c, guo h, lü f, xu y, li j, lou l. yn968d1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. cancer sci. 2011 jul;102(7):1374-80.
Apatinib Mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Apatinib Mesylate manufacturers
- Product
- Apatinib mesylate 1218779-75-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2019-12-31
- Product
- N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide methanesulfonate 1218779-75-9
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23