ALFENTANIL HYDROCHLORIDE

Product Name
ALFENTANIL HYDROCHLORIDE
CAS No.
69049-06-5
Chemical Name
ALFENTANIL HYDROCHLORIDE
Synonyms
D00835;Alfenta (tn);ALFENTANIL HYDROCHLORIDE;Alfentanyl Hydrochloride;AQORHZJDCHLLJN-UHFFFAOYSA-N;Alfentanil hydrochloride (usp);Alfentanil hydrochloride solution;Methanol(test AlfentanilHCl,1.0mg/mLasfreebase);N-[1-[2-(4-Ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidinyl]-N-phenyl-propanamide Hydrochloride;N-[1-[2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl]-N-phenylpropionamide hydrochloride
CBNumber
CB3261493
Molecular Formula
C21H33ClN6O3
Formula Weight
452.98
MOL File
69049-06-5.mol
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ALFENTANIL HYDROCHLORIDE Property

Melting point:
92-94?C
Flash point:
9℃
storage temp. 
Controlled Substance, -20°C Freezer
solubility 
Freely soluble in water, in ethanol (96 per cent) and in methanol.
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A-071
Product name
Alfentanil hydrochloride solution
Packaging
071-1ml
Price
$73
Updated
2020/08/18
Sigma-Aldrich
Product number
A-071
Product name
Alfentanil hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1 mL
Price
$75.3
Updated
2021/03/22
Cayman Chemical
Product number
19292
Product name
Alfentanil (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$293
Updated
2021/03/22
Cayman Chemical
Product number
19292
Product name
Alfentanil (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$65
Updated
2021/03/22
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ALFENTANIL HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Alfentanil is a narcotic analgesic with a more rapid onset and shorter duration of action than its structural relative fentanyl. The primary utility of alfentanil is in surgical analgesia/anesthesia, especially for cardiac compromised patients and in procedures of short duration.

Chemical Properties

Tan Solid

Originator

Jansseu (Belgium)

Uses

An opioid analgesic receptor agonist for pain treatment. Tetrazole derivative of Fentanyl. Analgesic (narcotic). Controlled substance (opiate)

Manufacturing Process

A mixture of 22 parts of 1-ethyl-1,4-dihydro-5H-tetrazol-5-one, 45 parts of 1- bromo-2-chloroethane, 26 parts of sodium carbonate, 0.3 part of potassium iodide and 240 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with water-separator. The reaction mixture is cooled, water is added and the layers are separated. The aqueous phase is extracted three times with dichloromethane. The combined organic phases are dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using trichloromethane as eluent. The pure fractions are collected and the eluent is evaporated, yielding 28.4 parts (80%) of 1-(2-chloroethyl)-4-ethyl- 1,4-dihydro-5H-tetrazol-5-one as a residue.
A mixture of 1.8 parts of 1-(2-chloroethyl)-4-ethyl-1,4-dihydro-5H-tetrazol-5- one, 3.45 parts of N-[4-(methoxymethyl)-4-piperidinyl]-Nphenylpropanamide, 5 parts of sodium carbonate, 0.2 part of potassium iodide and 240 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with water-separator. The reaction mixture is poured onto water and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is purified by column-chromatography over silicagel using a mixture of trichloromethane and methanol (97:3 by volume) as eluent. The pure fractions are collected and the eluent is evaporated. The residue is converted into the hydrochloride salt in 2-propanone. The salt is filtered off and crystallized from 2-propanone, yielding 1.5 parts (33.3%) of N-[1-[2-(4-ethyl- 4,5-dihydro-5-oxo-1H-tetrazol-1-yl]-4-(methoxymethyl)-4-piperidinyl]-Nphenylpropanamide monohydrochloride monohydrate; melting point 140.8°C.

brand name

Alfenta (Akorn);RAPIFEN.

Therapeutic Function

Narcotic analgesic

ALFENTANIL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ALFENTANIL HYDROCHLORIDE Suppliers

69049-06-5, ALFENTANIL HYDROCHLORIDERelated Search:


  • N-[1-[2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl]-N-phenylpropionamide hydrochloride
  • Alfentanyl Hydrochloride
  • N-[1-[2-(4-Ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidinyl]-N-phenyl-propanamide Hydrochloride
  • AQORHZJDCHLLJN-UHFFFAOYSA-N
  • Alfenta (tn)
  • Alfentanil hydrochloride (usp)
  • D00835
  • Methanol(test AlfentanilHCl,1.0mg/mLasfreebase)
  • Alfentanil hydrochloride solution
  • N-[1-[2-(4-Ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide monohydrochloride
  • ALFENTANIL HYDROCHLORIDE
  • N-(1-(2-(4-ethyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethyl)-4-(methoxymethyl)piperidin-4-yl)-N-phenylpropionamide hydrochloride
  • 69049-06-5
  • C21H33ClN6O3
  • C21H32N6O3HCl
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  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals