3-hydroxypyridine-4-carbonitrile
- Product Name
- 3-hydroxypyridine-4-carbonitrile
- CAS No.
- 87032-82-4
- Chemical Name
- 3-hydroxypyridine-4-carbonitrile
- Synonyms
- 4-Cyano-3-hydroxypyridine;3-Hydroxyisonicotinonitrile;3-hydroxypyridine-4-carbonitrile;3-hydroxy-4-Pyridinecarbonitrile;4-Pyridinecarbonitrile, 3-hydroxy-;3-hydroxyisonicotinonitrile - [AC80458];6- (tert butyl aminomethyl) isonicotinic acid;3-Hydroxypyridine-4-carbonitrile, 4-Cyano-3-hydroxypyridine
- CBNumber
- CB32616383
- Molecular Formula
- C6H4N2O
- Formula Weight
- 120.11
- MOL File
- 87032-82-4.mol
3-hydroxypyridine-4-carbonitrile Property
- Melting point:
- 166 °C
- Boiling point:
- 393.6±27.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 5.38±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H954960
- Product name
- 3-hydroxyisonicotinonitrile
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- H954960
- Product name
- 3-hydroxyisonicotinonitrile
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CHM0389204
- Product name
- 3-HYDROXYISONICOTINONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.92
- Updated
- 2021/12/16
- Product number
- 3723AC
- Product name
- 3-Hydroxyisonicotinonitrile
- Packaging
- 5g
- Price
- $1670
- Updated
- 2021/12/16
- Product number
- 3723AC
- Product name
- 3-Hydroxyisonicotinonitrile
- Packaging
- 1g
- Price
- $725
- Updated
- 2021/12/16
3-hydroxypyridine-4-carbonitrile Chemical Properties,Usage,Production
Synthesis
945989-08-2
87032-82-4
Step C: Preparation of 3-hydroxyisonicotinonitrile: 3-(2-(trimethylmethylsilyl)ethoxy)isonicotinonitrile (1.30 g, 5.90 mmol) and anhydrous THF (5 mL) were added to a dry reaction flask, followed by slow addition of ammonium fluoride (11.8 mL, 11.8 mmol) to the THF solution. The reaction mixture was stirred at room temperature for 1 h, after which the solvent was removed by concentration via rotary evaporator. The crude product was purified by silica gel column chromatography using sequentially dichloromethane and dichloromethane solution containing 5% methanol as eluents to afford the target product 3-hydroxyisonicotinonitrile (0.7 g, 99% yield) as a dark brown oil.
References
[1] Patent: WO2008/91770, 2008, A1. Location in patent: Page/Page column 32
[2] Patent: WO2007/89512, 2007, A1. Location in patent: Page/Page column 194
3-hydroxypyridine-4-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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