Methyl 5-amino-2-chloroisonicotinate
- Product Name
- Methyl 5-amino-2-chloroisonicotinate
- CAS No.
- 1073182-59-8
- Chemical Name
- Methyl 5-amino-2-chloroisonicotinate
- Synonyms
- methyl 5-amino-2-chloroisonicotinate;Methyl 5-amino-2-chloroisonicotinate 95%;Methyl 5-aMino-2-chloropyridine-4-carboxylate;4-Pyridinecarboxylic acid, 5-amino-2-chloro-, methyl ester;Methyl 5-amino-2-chloropyridine-4-carboxylate, 5-Amino-2-chloro-4-(methoxycarbonyl)pyridine
- CBNumber
- CB32616686
- Molecular Formula
- C7H7ClN2O2
- Formula Weight
- 186.6
- MOL File
- 1073182-59-8.mol
Methyl 5-amino-2-chloroisonicotinate Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- M333108
- Product name
- Methyl5-Amino-2-chloroisonicotinate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 1540AA
- Product name
- Methyl5-amino-2-chloroisonicotinate
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- HCH0047678
- Product name
- 5-AMINO-2-CHLORO-ISONICOTINIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $499.8
- Updated
- 2021/12/16
- Product number
- OR46528
- Product name
- Methyl5-amino-2-chloroisonicotinate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $508
- Updated
- 2021/12/16
- Product number
- 4H58-5-X0
- Product name
- Methyl 5-amino-2-chloroisonicotinate
- Packaging
- 250mg
- Price
- $560
- Updated
- 2021/12/16
Methyl 5-amino-2-chloroisonicotinate Chemical Properties,Usage,Production
Synthesis
67-56-1
171178-46-4
1073182-59-8
To a stirred solution of 5-tert-butoxycarbonylamino-2-chloroisonicotinic acid (crude, 8.0 g) in methanol (50 mL) was slowly added concentrated sulfuric acid (5.0 mL). The reaction mixture was heated to reflux and kept at this condition for the reaction overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was diluted with an appropriate amount of water and then neutralized with saturated sodium bicarbonate solution to pH=8. The neutralized aqueous phase was extracted with ethyl acetate (100 mL x2). The organic phases were combined and washed with saturated brine (50 mL), followed by drying with anhydrous sodium sulfate and filtration. The filtrate was evaporated to dryness under reduced pressure and the resulting crude product was purified by silica gel column chromatography.
References
[1] Patent: WO2015/200534, A2. Location in patent: Paragraph 00480
[1] Patent: , 2015, . Location in patent: Paragraph 00480
Methyl 5-amino-2-chloroisonicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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