1-(4-bromophenyl)cyclobutanol
- Product Name
- 1-(4-bromophenyl)cyclobutanol
- CAS No.
- 19936-14-2
- Chemical Name
- 1-(4-bromophenyl)cyclobutanol
- Synonyms
- 1-(4-bromophenyl)cyclobutanol;1-（4-bromophenyl）cyclobutylol;Cyclobutanol, 1-(4-bromophenyl)-;1-(4-bromophenyl)cyclobutan-1-ol;2-methylthiazole-24-carboxylic acid
- CBNumber
- CB32617476
- Molecular Formula
- C10H11BrO
- Formula Weight
- 227.1
- MOL File
- 19936-14-2.mol
1-(4-bromophenyl)cyclobutanol Property
- Boiling point:
- 306.1±25.0 °C(Predicted)
- Density
- 1.547±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.29±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B293110
- Product name
- 1-(4-Bromophenyl)cyclobutanol
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 2721CT
- Product name
- 1-(4-Bromophenyl)cyclobutanol
- Packaging
- 5g
- Price
- $667
- Updated
- 2021/12/16
- Product number
- A298479
- Product name
- 1-(4-Bromophenyl)cyclobutanol
- Purity
- 95%
- Packaging
- 100mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- A298479
- Product name
- 1-(4-Bromophenyl)cyclobutanol
- Purity
- 95%
- Packaging
- 250mg
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 28513
- Product name
- 1-(4-Bromophenyl)cyclobutanol
- Purity
- 97%
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
1-(4-bromophenyl)cyclobutanol Chemical Properties,Usage,Production
Synthesis
1191-95-3
589-87-7
19936-14-2
Preparation of the intermediate 1-(4-bromophenyl)cyclobutanol (10-1): 1-bromo-4-iodobenzene (1.6293 g, 5.75 mmol) was dissolved in anhydrous tetrahydrofuran (10 mL). The reaction system was cooled to -78 °C, n-butyllithium (2.5 M hexane solution, 2.42 mL, 6.05 mmol) was slowly added under nitrogen protection and stirred continuously at -78 °C for 20 min. Subsequently, cyclobutanone (0.448 mL, 6.05 mmol) was added dropwise to the above cold solution. After the dropwise addition, the reaction system was gradually warmed to room temperature and stirring was continued for 16 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution and extracted with a 1:1 (v/v) mixture of ethyl acetate/tetrahydrofuran. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product as a thick oil. The crude product was purified by silica gel column chromatography using 0% to 30% ethyl acetate/heptane gradient elution to afford the target compound 1-(4-bromophenyl)cyclobutanol (0.8033 g, 65% yield) as a clear oil.
References
[1] Patent: WO2010/86820, 2010, A1. Location in patent: Page/Page column 42
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 17, p. 8068 - 8081
[3] Patent: EP3342765, 2018, A1. Location in patent: Paragraph 0269
1-(4-bromophenyl)cyclobutanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(4-bromophenyl)cyclobutanol manufacturers
- Product
- 1-(4-bromophenyl)cyclobutanol 19936-14-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-05