Plazomicin

Product Name: Plazomicin
CAS No.: 1154757-24-0
Chemical Name: Plazomicin
Synonyms: ACHN 490;PlazoMicin;Plazomicin API;Sisomicin Impurity 10;IYDYFVUFSPQPPV-BPUQVFSTSA-N;Pirimicarb Impurity 9 (Ethirimol);O-2-AMino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)aMino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-Methyl-3-(MethylaMino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-aMino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptaMine;D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)amino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-
CBNumber: CB32622979
Molecular Formula: C25H48N6O10
Formula Weight: 592.68282
MOL File: 1154757-24-0.mol

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Plazomicin Property

Melting point:: >185°C (dec.)
Boiling point:: 896.4±65.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Water (Slightly)
form: Solid
pka: 13.11±0.20(Predicted)
color: Pale Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Medical Isotopes, Inc.

Product number: 48368
Product name: Plazomicin
Packaging: 25mg
Price: $13500
Updated: 2021/12/16

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Plazomicin Chemical Properties,Usage,Production

Description

Plazomicin (PLZ) is a novel aminoglycoside approved by the U.S. Food and Drug Administration (FDA) for the treatment of complicated urinary tract infections (cUTI, including acute pyelonephritis) in adults due to multidrug-resistant carbapenem-resistant Enterobacterales (CRE) or extended-spectrum beta-lactamase (ESBL) producing bacteria. Despite the FDA Black Box Warning for aminoglycoside class effects, PLZ exhibited a favourable safety profile with decreased adverse effects in the largest in-human trials. In vitro, activity of PLZ, in comparison with that of other aminoglycosides, was found to be excellent, with 92.3% to 98.0% overall susceptibility in Enterobacterales, including CRE. Recently, PLZ was also shown to be active against certain multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative pathogens for which limited treatment options are left[1-2].

References

[1] Kristy M Shaeer. “Plazomicin: A Next-Generation Aminoglycoside.” Pharmacotherapy 39 1 (2019): 77–93.
[2] Laurine S Blanchard. “Multicenter Clinical Evaluation of ETEST Plazomicin (PLZ) for Susceptibility Testing of Enterobacterales.” Journal of Clinical Microbiology 60 1 (2022): e0183121.

Plazomicin Preparation Products And Raw materials

Raw materials

Preparation Products

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Plazomicin Suppliers

Canada 1 China 31 India 4 United Kingdom 1 United States 1 Global 38

Chemsky (shanghai) International Co.,Ltd

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View Lastest Price from Plazomicin manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: ACHN 490 1154757-24-0
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-10-29

Shaanxi Dideu Medichem Co. Ltd

Product: Plazomicin 1154757-24-0
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-08-04

1154757-24-0, PlazomicinRelated Search:

ACHN 490

O-2-AMino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)aMino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-Methyl-3-(MethylaMino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-aMino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptaMine

PlazoMicin

IYDYFVUFSPQPPV-BPUQVFSTSA-N

D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)amino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-

Plazomicin API

Pirimicarb Impurity 9 (Ethirimol)

Sisomicin Impurity 10

1154757-24-0

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Oligosaccharides

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