ChemicalBook > CAS DataBase List > SRT2104 (GSK2245840)

SRT2104 (GSK2245840)

Product Name
SRT2104 (GSK2245840)
CAS No.
1093403-33-8
Chemical Name
SRT2104 (GSK2245840)
Synonyms
CS-2293;GSK2245840;sirtuin Modulator;SRT-2104;SRT 2104;SRT2104 (GSK2245840);SRT2104 (GSK2245840) USP/EP/BP;SRT 2104,Sirtuin,Inhibitor,SRT-2104,inhibit;(E)-3-(3-HYDROXY-4-METHOXYPHENYL)PROP-2-ENOIC ACID;4-methyl-N-(2-(3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-(yridine-3-yl)thiazole-5-carboxamide;4-Methyl-N-[2-[3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-(pyridin-3-yl)thiazole-5-carboxamide
CBNumber
CB32624034
Molecular Formula
C26H24N6O2S2
Formula Weight
516.64
MOL File
1093403-33-8.mol
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SRT2104 (GSK2245840) Property

Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥6.46 mg/mL in DMSO with gentle warming
form 
Powder
pka
11.40±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28380
Product name
SRT 2104
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
28380
Product name
SRT 2104
Packaging
25mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
28380
Product name
SRT 2104
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
28380
Product name
SRT 2104
Packaging
10mg
Price
$299
Updated
2024/03/01
Biosynth Carbosynth
Product number
FM71744
Product name
SRT2104
Packaging
25mg
Price
$325
Updated
2021/12/16
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SRT2104 (GSK2245840) Chemical Properties,Usage,Production

Biological Activity

srt2104 (gsk2245840) is a selective sirt1 activator involved in the regulation of energy homeostasis. sirt1, also known as nad-dependent deacetylase sirtuin-1, is a member of the sirtuin family of proteins.

in vitro

in c2c12 myoblasts stably transfected with small hairpin rna to knock-down sirt1, srt2104 increased ap activity, a marker for osteogenic differentiation. this effect was totally dependent on sirt1 expression [1].

in vivo

in male c57bl/6j mice, administration of srt2104 (100 mg/kg, p.o.) extended both mean and maximal lifespan of mice fed a standard diet, and enhanced bone mineral density, motor coordination, and insulin sensitivity and decreased inflammation. short-term srt2104 administration preserved bone and muscle mass in an experimental model of atrophy [1]. in male n171-82q hd mice with huntington's disease, srt2104 (diet containing 0.5% srt2104) effectively penetrated the blood-brain barrier, attenuated brain atrophy, improved motor function, and extended survival [2].

References

[1]. mercken e m, mitchell s j, martin‐montalvo a, et al. srt2104 extends survival of male mice on a standard diet and preserves bone and muscle mass[j]. aging cell, 2014, 13(5): 787-796.
[2]. jiang m, zheng j, peng q, et al. sirtuin 1 activator srt2104 protects huntington's disease mice[j]. annals of clinical and translational neurology, 2014, 1(12): 1047-1052.

SRT2104 (GSK2245840) Preparation Products And Raw materials

Raw materials

Preparation Products

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1093403-33-8, SRT2104 (GSK2245840)Related Search:

SRT3025 SRT1720 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide 5-Aza-2'-deoxycytidine 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Dasatinib Dabrafenib PF-04691502 Sunitinib Malate

  • SRT2104 (GSK2245840)
  • (E)-3-(3-HYDROXY-4-METHOXYPHENYL)PROP-2-ENOIC ACID
  • GSK2245840
  • 5-ThiazolecarboxaMide, 4-Methyl-N-[2-[3-(4-MorpholinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]-2-(3-pyridinyl)-
  • sirtuin Modulator
  • 4-Methyl-N-[2-[3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-(pyridin-3-yl)thiazole-5-carboxamide
  • CS-2293
  • SRT-2104;SRT 2104
  • 4-methyl-N-(2-(3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-(yridine-3-yl)thiazole-5-carboxamide
  • 4-methyl-N-[2-[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-pyridin-3-yl-1,3-thiazole-5-carboxamide
  • SRT2104 (GSK2245840) USP/EP/BP
  • SRT 2104,Sirtuin,Inhibitor,SRT-2104,inhibit
  • 1093403-33-8
  • Inhibitors