ChemicalBook > CAS DataBase List > BMS-265246

BMS-265246

Product Name
BMS-265246
CAS No.
582315-72-8
Chemical Name
BMS-265246
Synonyms
CS-984;BMS-265246;BMS-265246, >=98%;BMS-265246 USP/EP/BP;BMS265246; BMS 265246;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone;Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone BMS265246
CBNumber
CB32624100
Molecular Formula
C18H17F2N3O2
Formula Weight
345.34
MOL File
582315-72-8.mol
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BMS-265246 Property

Boiling point:
552.9±50.0 °C(Predicted)
Density 
1.304±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥17.25 mg/mL in DMSO
form 
solid
pka
8.50±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19168
Product name
BMS-265246
Purity
≥95%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
19168
Product name
BMS-265246
Purity
≥95%
Packaging
5mg
Price
$270
Updated
2024/03/01
Tocris
Product number
5654
Product name
BMS265246
Purity
≥97%(HPLC)
Packaging
10
Price
$189
Updated
2021/12/16
Tocris
Product number
5654
Product name
BMS265246
Purity
≥97%(HPLC)
Packaging
50
Price
$794
Updated
2021/12/16
Usbiological
Product number
004336
Product name
BMS-265246
Packaging
5mg
Price
$566
Updated
2021/12/16
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BMS-265246 Chemical Properties,Usage,Production

Uses

BMS-265246 is a potent and selective pyra-zolopyridine based inhibitor of cdk2/cyclinE, cdk1/cyclinB and cdk4/ cyclinD.

Biological Activity

bms265246 is a potent and selective inhibitor for cdk1 and cdk2 (ic50= 6 nm and 9 nm)cyclin-dependent kinases (cdk) are a group of serine/threonine kinases. they are activated by coupling to cyclin and participate in the regulation of cell cycle.bms265246 inhibited the cdk4/cycd activity and prevented a2780 cytox (ic50 = 0.23 μm and 0.76 μm) [1]. in hct-116 cells, bms-265246 blocked the cell proliferation (ec50= 0.293 μm—0.492 μm). following the treatment of bms-265246, low dna intensity, large round nuclei and 4n dna content were observed in the dominant cell population –g2 arrested cells. [2]

storage

Store at -20°C

References

1. misra rn, xiao hy, rawlins db et al. 1h-pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-difluorophenacyl analogues. bioorgmed chem lett. 2003 jul 21;13(14):2405-8.2. sutherland jj, low j, blosser w et al. a robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. mol cancer ther. 2011 feb;10(2):242-54.

BMS-265246 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-265246 Suppliers

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582315-72-8, BMS-265246Related Search:

PHA-848125 AZD 5438 Ribociclib BS-181 HCl PD 0332991 HCl Abemaciclib mesylate (LY2835219)

  • BMS-265246
  • BMS-265246, >=98%
  • (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone
  • (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone BMS265246
  • BMS265246; BMS 265246
  • CS-984
  • Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-
  • BMS-265246 USP/EP/BP
  • 582315-72-8
  • Inhibitors