ChemicalBook > CAS DataBase List > BMS-265246

BMS-265246

Product Name
BMS-265246
CAS No.
582315-72-8
Chemical Name
BMS-265246
Synonyms
CS-984;BMS-265246;BMS-265246, >=98%;BMS-265246 USP/EP/BP;BMS265246; BMS 265246;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone;Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone BMS265246
CBNumber
CB32624100
Molecular Formula
C18H17F2N3O2
Formula Weight
345.34
MOL File
582315-72-8.mol
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BMS-265246 Property

Boiling point:
552.9±50.0 °C(Predicted)
Density 
1.304±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥17.25 mg/mL in DMSO
form 
solid
pka
8.50±0.40(Predicted)
color 
White to pink
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19168
Product name
BMS-265246
Purity
≥95%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
19168
Product name
BMS-265246
Purity
≥95%
Packaging
5mg
Price
$270
Updated
2024/03/01
Tocris
Product number
5654
Product name
BMS265246
Purity
≥97%(HPLC)
Packaging
10
Price
$189
Updated
2021/12/16
Tocris
Product number
5654
Product name
BMS265246
Purity
≥97%(HPLC)
Packaging
50
Price
$794
Updated
2021/12/16
Usbiological
Product number
004336
Product name
BMS-265246
Packaging
5mg
Price
$566
Updated
2021/12/16
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BMS-265246 Chemical Properties,Usage,Production

Uses

BMS-265246 is a potent and selective pyra-zolopyridine based inhibitor of cdk2/cyclinE, cdk1/cyclinB and cdk4/ cyclinD.

Biological Activity

bms265246 is a potent and selective inhibitor for cdk1 and cdk2 (ic50= 6 nm and 9 nm)cyclin-dependent kinases (cdk) are a group of serine/threonine kinases. they are activated by coupling to cyclin and participate in the regulation of cell cycle.bms265246 inhibited the cdk4/cycd activity and prevented a2780 cytox (ic50 = 0.23 μm and 0.76 μm) [1]. in hct-116 cells, bms-265246 blocked the cell proliferation (ec50= 0.293 μm—0.492 μm). following the treatment of bms-265246, low dna intensity, large round nuclei and 4n dna content were observed in the dominant cell population –g2 arrested cells. [2]

storage

Store at -20°C

References

1. misra rn, xiao hy, rawlins db et al. 1h-pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-difluorophenacyl analogues. bioorgmed chem lett. 2003 jul 21;13(14):2405-8.2. sutherland jj, low j, blosser w et al. a robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. mol cancer ther. 2011 feb;10(2):242-54.

BMS-265246 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-265246 Suppliers

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582315-72-8, BMS-265246Related Search:

PHA-848125 AZD 5438 Ribociclib BS-181 HCl PD 0332991 HCl Abemaciclib mesylate (LY2835219)

  • BMS-265246
  • BMS-265246, >=98%
  • (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone
  • (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone BMS265246
  • BMS265246; BMS 265246
  • CS-984
  • Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-
  • BMS-265246 USP/EP/BP
  • 582315-72-8
  • Inhibitors