ChemicalBook > CAS DataBase List > SMND-309

SMND-309

Product Name: SMND-309
CAS No.: 1065559-56-9
Chemical Name: SMND-309
Synonyms: SMND-309;SMND 309;SMND309;(2E)-2-[6-[(E)-2-Carboxyvinyl]-2,3-dihydroxyphenyl]-3-(3,4-dihydroxyphenyl)acrylic acid;Benzeneacetic acid, 6-[(1E)-2-carboxyethenyl]-α-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydroxy-, (αE)-
CBNumber: CB32624296
Molecular Formula: C18H14O8
Formula Weight: 358.3
MOL File: 1065559-56-9.mol

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SMND-309 Property

Melting point:: >400℃
Boiling point:: 667.1±55.0 °C(Predicted)
Density: 1.655
storage temp.: Store at -20°C
solubility: DMSO: ≥ 3.7 mg/mL (10.33 mM)
pka: 3.20±0.10(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0014146
Product name: SMND-309
Purity: 95.00%
Packaging: 5MG
Price: $421.3
Updated: 2021/12/16

DC Chemicals

Product number: DC9531
Product name: SMND-309
Purity: >98%
Packaging: 100mg
Price: $1050
Updated: 2021/12/16

DC Chemicals

Product number: DC9531
Product name: SMND-309
Purity: >98%
Packaging: 1g
Price: $4200
Updated: 2021/12/16

Crysdot

Product number: CD31004664
Product name: SMND-309
Purity: 98+%
Packaging: 5mg
Price: $129
Updated: 2021/12/16

Crysdot

Product number: CD31004664
Product name: SMND-309
Purity: 98+%
Packaging: 10mg
Price: $229
Updated: 2021/12/16

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SMND-309 Chemical Properties,Usage,Production

Uses

SMND-309 is a metabolite of salvianolic acid B, and exhibits neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats[1][2].

in vivo

SMND-309 (2.5-10 mg/kg; oral intragastric; once a day; for 4 weeks; male Sprague-Dawley rats) treatment ameliorates liver function and decreases the elevation of serum hyaluronic acid, laminin, procollagen type III levels and hydroxyproline content in liver tissue. SMND-309 also decreases the elevation in the malondialdehyde level and restored the decrease in superoxide dismutase and glutathione peroxidase activities. SMND-309 treatment reduces the liver damage and the liver fibrosis grade. SMND-309 treatment powerfully down-regulated the expression of connective tissue growth factor (CTGF) in serum and liver^[1].

Animal Model:	Male Sprague-Dawley rats (180-200 g) with carbon tetrachloride^[1]
Dosage:	2.5 mg/kg, 5 mg/kg and 10 mg/kg
Administration:	Oral intragastric; once a day; for 4 weeks
Result:	The antifibrotic mechanisms might be associated with its ability to suppress the expression of CTGF as well as scavenge lipid peroxidation products and increase endogenous antioxidant enzyme activity.

References

[1] Hou J, Tian J, Jiang W, Gao Y, Fu F. Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis. Eur J Pharmacol. 2011 Jan 10;650(1):390-5. DOI:10.1016/j.ejphar.2010.10.019
[2] Yang J, Zhang G, Tian J, Li C, Jiang W, Xing Y, Zhu H, Hou J, Xu H, Wu J. Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats. Basic Clin Pharmacol Toxicol. 2010 Apr;106(4):317-23. DOI:10.1111/j.1742-7843.2009.00490.x
[3] Wang Y, Zhang J, Han M, et al. SMND-309 promotes neuron survival through the activation of the PI3K/Akt/CREB-signalling pathway. Pharm Biol. 2016;54(10):1982-1990. DOI:10.3109/13880209.2015.1137951

SMND-309 Preparation Products And Raw materials

Raw materials

Preparation Products

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1065559-56-9, SMND-309Related Search:

SMND-309

(2E)-2-[6-[(E)-2-Carboxyvinyl]-2,3-dihydroxyphenyl]-3-(3,4-dihydroxyphenyl)acrylic acid

SMND 309;SMND309

Benzeneacetic acid, 6-[(1E)-2-carboxyethenyl]-α-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydroxy-, (αE)-

1065559-56-9