AH3960
- Product Name
- AH3960
- CAS No.
- 862907-48-0
- Chemical Name
- AH3960
- Synonyms
- AH3960;AH-3960 (AH 3960;1,3-Dibutyl-5-(diaminomethylene)pyrimidine-2,4,6-trione;1,3-dibutyl-5-(diaminomethylidene)-1,3-diazinane-2,4,6-trione;2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dibutyl-5-(diaminomethylene)-
- CBNumber
- CB32627303
- Molecular Formula
- C13H22N4O3
- Formula Weight
- 282.34
- MOL File
- 862907-48-0.mol
AH3960 Property
- form
- Solid
- color
- White to light yellow
N-Bromosuccinimide Price
- Product number
- INB0001431
- Product name
- AH-3960
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.72
- Updated
- 2021/12/16
AH3960 Chemical Properties,Usage,Production
Description
AH-3960 is an agonist of thyroid hormone receptor-1 (PTHR1).
Uses
AH3960 (compound 16c) is an antagonist of androgen receptor. AH3960 binds wild as well as T877 mutant type androgen receptors. AH3960 selectively inhibits T877 with an IC50 value of 0.82 μM. AH3960 also serves as an agonist of parathyroid hormone receptor-1 (PTHR1)[1][2].
References
[1] Yamamoto S, et al. Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists. Bioorg Med Chem. 2012 Apr 1;20(7):2338-52. DOI:10.1016/j.bmc.2012.02.005
[2] Carter PH, et al. Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Mol Endocrinol. 2015 Feb;29(2):307-21. DOI:10.1210/me.2014-1129
AH3960 Preparation Products And Raw materials
Raw materials
Preparation Products
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