AZD3514

Product Name: AZD3514
CAS No.: 1240299-33-5
Chemical Name: AZD3514
Synonyms: CS-795;AZD3514;AZD3514 ，S7040;AZD3514 USP/EP/BP;AZD 3514; AZD-3514;AZD3514, 10 mM in DMSO;AZD3514;AZD-3514;AZD 3514;Baicalein 7-O-β-D-glucuronide;1-(4-(2-(4-(1-(3-(Trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-;1-[4-[2-[4-[1-[7,8-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]-4-piperidinyl]phenoxy]ethyl]-1-piperazinyl]-ethanone
CBNumber: CB32627358
Molecular Formula: C25H32F3N7O2
Formula Weight: 519.56
MOL File: 1240299-33-5.mol

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AZD3514 Property

Boiling point:: 669.5±65.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥24.45 mg/mL in DMSO; insoluble in H2O; ≥46.4 mg/mL in EtOH
form: solid
pka: 6.31±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: 378280
Product name: AZD-3514
Packaging: 10mg
Price: $460
Updated: 2021/12/16

ApexBio Technology

Product number: A1372
Product name: AZD3514
Packaging: 10mM(in 1mL DMSO)
Price: $90
Updated: 2021/12/16

ApexBio Technology

Product number: A1372
Product name: AZD3514
Packaging: 10mg
Price: $120
Updated: 2021/12/16

ApexBio Technology

Product number: A1372
Product name: AZD3514
Packaging: 50mg
Price: $330
Updated: 2021/12/16

ApexBio Technology

Product number: A1372
Product name: AZD3514
Packaging: 100mg
Price: $540
Updated: 2021/12/16

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AZD3514 Chemical Properties,Usage,Production

Uses

AZD3514 is an orally activie and selective androgen receptor (AR) inhibitor. AZD3514 androgen-dependently and -independently inhibits AR signal. AZD351 down-regulates nuclear AR levels in human LNCaP prostate cancer cells in the absence of androgen with an pIC50 value of 5.75. AZD3514 can be used for the research of prostate cancer[1][2][3].

in vivo

AZD3514 (10-100 mg/kg; p.o. once daily for 6 days) inhibits AR signaling in rats^[2]. AZD3514 (50 mg/kg; p.o. once daily for 30 days) inhibits prostate tumor growth^[2]. AZD3514 (50-100 mg/kg; p.o. once daily for 3 days) significantly reduces nuclear AR protein in vivo^[2].

Animal Model:	Intact or castrat 42- and 49-day-old Hans Wistar rats^[2]
Dosage:	10, 50 and 100 mg/kg
Administration:	Oral gavage; 10-100 mg/kg once daily; for 6 days
Result:	Inhibited AR signaling in rats, reduced seminal vesicle weight in intact rats, and inhibited the ability of exogenous testosterone proprionate to cause an increase in seminal vesicle weight in castrated rat.

Animal Model:	Male Copenhagen rats with Dunning R3327H prostate tumors^[2]
Dosage:	50 mg/kg
Administration:	Oral gavage; 50 mg/kg once daily; for 30 days
Result:	Significantly inhibited prostate tumor growth of rats.

target

androgen receptor

References

[1] Bradbury RH, et al. Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1945-8. DOI:10.1016/j.bmcl.2013.02.056
[2] Loddick SA, et al. AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo. Mol Cancer Ther. 2013 Sep;12(9):1715-27. DOI:10.1158/1535-7163.MCT-12-1174
[3] Omlin A, et al. AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer - results of two parallel first-in-human phase I studies. Invest New Drugs. 2015 Jun;33(3):679-90. DOI:10.1007/s10637-015-0235-5

AZD3514 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD3514 Suppliers

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1240299-33-5, AZD3514Related Search:

Galeterone

AZD3514

1-[4-[2-[4-[1-[7,8-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]-4-piperidinyl]phenoxy]ethyl]-1-piperazinyl]-ethanone

Ethanone, 1-[4-[2-[4-[1-[7,8-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]-4-piperidinyl]phenoxy]ethyl]-1-piperazinyl]-

1-(4-(2-(4-(1-(3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethanone

AZD3514;AZD-3514;AZD 3514

1-(4-(2-(4-(1-(3-(Trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-

AZD 3514; AZD-3514

CS-795

AZD3514 USP/EP/BP

Baicalein 7-O-β-D-glucuronide

1-(4-(2-(4-(1-(3-(Trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethan-1-one

AZD3514, 10 mM in DMSO

AZD3514 ，S7040

1240299-33-5

C25H32F3N7O2

Inhibitors