ChemicalBook > CAS DataBase List > EL-102
EL-102
- Product Name
- EL-102
- CAS No.
- 1233948-61-2
- Chemical Name
- EL-102
- Synonyms
- EL-102;EL-102; EL 102;EL-102, 10 mM in DMSO;Benzenesulfonamide, N-[5-(5-cyano-3-thienyl)-2-methylphenyl]-4-methoxy-;N-[5-(5-cyano-thiophen-3-yl)-2-methyl-phenyl]-4-methoxy-benzenesulfonamide
- CBNumber
- CB32627792
- Molecular Formula
- C19H16N2O3S2
- Formula Weight
- 384.47
- MOL File
- 1233948-61-2.mol
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EL-102 Property
- Boiling point:
- 548.1±60.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:36.0(Max Conc. mg/mL);93.64(Max Conc. mM)
- form
- Solid
- pka
- 8.14±0.10(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-5641
- Product name
- EL-102
- Purity
- 99.07%
- Packaging
- 5mg
- Price
- $336
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-5641
- Product name
- EL-102
- Purity
- 99.07%
- Packaging
- 50mg
- Price
- $1140
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-5641
- Product name
- EL-102
- Purity
- 99.07%
- Packaging
- 100mg
- Price
- $1800
- Updated
- 2021/12/16
Crysdot
- Product number
- CD31004158
- Product name
- EL-102
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $194
- Updated
- 2021/12/16
Crysdot
- Product number
- CD31004158
- Product name
- EL-102
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $312
- Updated
- 2021/12/16
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EL-102 Chemical Properties,Usage,Production
Uses
EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer[1].
in vivo
EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo[1].
| Animal Model: | Nude mice with CWR22 xenografts[1] |
| Dosage: | 12 and 15 mg/kg |
| Administration: | Oral gavage; 12 and 15 mg/kg 5-day on and 2-day off; from 13 to 37 days after tumour transplantation |
| Result: | Showed no effect on tumor growth, but enhanced the effect of docetaxel on tumor . |
References
[1] A P Toner et al. The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivoactivity against prostate cancer and circumvents MDR1 resistance. Br J Cancer, 2013 Oct 15, 109(8): 2131-2141. DOI:10.1038/bjc.2013.537
EL-102 Preparation Products And Raw materials
Raw materials
Preparation Products
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EL-102 Suppliers
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