JDTic

Product Name: JDTic
CAS No.: 361444-66-8
Chemical Name: JDTic
Synonyms: JDTic;(3R)-7-HYDROXY-N-[(2S)-1-[(3R,4R)-4-(3-HYDROXYPHENYL)-3,4-DIMETHYLPIPERIDIN-1-YL]-3-METHYLBUTAN-2-YL]-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE;(3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide;3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3R)-
CBNumber: CB32627989
Molecular Formula: C28H39N3O3
Formula Weight: 465.62756
MOL File: 361444-66-8.mol

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JDTic Property

Boiling point:: 701.9±60.0 °C(Predicted)
Density: 1.129
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 9.96±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3517
Product name: JDTic
Packaging: 5mg
Price: $226
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0012931
Product name: (R)-7-HYDROXY-N-((S)-1-((3R,4R)-4-(3-HYDROXYPHENYL)-3,4-DIMETHYLPIPERIDIN-1-YL)-3-METHYLBUTAN-2-YL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $333.3
Updated: 2021/12/16

ApexBio Technology

Product number: A3517
Product name: JDTic
Packaging: 10mg
Price: $355
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0012931
Product name: (R)-7-HYDROXY-N-((S)-1-((3R,4R)-4-(3-HYDROXYPHENYL)-3,4-DIMETHYLPIPERIDIN-1-YL)-3-METHYLBUTAN-2-YL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE
Purity: 95.00%
Packaging: 1G
Price: $1083.39
Updated: 2021/12/16

ApexBio Technology

Product number: A3517
Product name: JDTic
Packaging: 50mg
Price: $1369
Updated: 2021/12/16

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JDTic Chemical Properties,Usage,Production

Uses

JDTic is a highly selective antagonist of κ-opioid receptor (KOR).

Biological Activity

ki = 0.3 nmjdtic is a selective opioid kappa receptor antagonist.at least three opioid receptor subtypes, μ, δ, and κ, are responsible for the modulation of a diverse array of biological events from nociception to immune regulation. the baisi of studying this complex receptor system is for the identification of both agonists and antagonists with high degree of receptor subtype selectivity.

in vitro

jdtic demonstrated high affinity for the κ receptor in the binding assay and highly potent and selective κ antagonism in the [35s]gtp-γ-s assay. jdtic showed a 16-fold improvement in its κ receptor ki value in the functional assay relative to the binding assay. in the [35s]gtp-γ-s functional assay, jdtic demonstrated a 3.4-fold increase in κ antagonist potency relative to the functional assay utilizing guinea pig membranes [1].

in vivo

jdtic was found to be able to dose-dependently block acute nicotineinduced antinociception in the tail-flick but not the hotplate test and did not attenuate morphine's antinociceptive effect significantly in either test. moreover, jdtic failed to block the expression of nicotine reward as measured by the conditioned place preference model. in contrast, jdtic attenuated the expression of both physical and affective nicotine withdrawal signs in mice[2].

References

[1] thomas jb,atkinson rn,rothman rb,fix se,mascarella sw,vinson na,xu h,dersch cm,lu y,cantrell be,zimmerman dm,carroll fi. identification of the first trans-(3r,4r)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity. j med chem.2001 aug 16;44(17):2687-90.
[2] jackson kj,carroll fi,negus ss,damaj mi. effect of the selective kappa-opioid receptor antagonist jdtic on nicotine antinociception, reward, and withdrawal in the mouse. psychopharmacology (berl).2010 jun;210(2):285-94.

JDTic Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from JDTic manufacturers

Career Henan Chemica Co

Product: JDTic 361444-66-8
Price: US $0.01/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1kg; 5kg; 10kg
Release date: 2020-10-28

Shanghai CRM New Material Technology Co., LTD

Product: JDTic 361444-66-8
Price: US $10.00-15.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10t
Release date: 2022-09-21

361444-66-8, JDTicRelated Search:

JDTic

(3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide

3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3R)-

(3R)-7-HYDROXY-N-[(2S)-1-[(3R,4R)-4-(3-HYDROXYPHENYL)-3,4-DIMETHYLPIPERIDIN-1-YL]-3-METHYLBUTAN-2-YL]-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE

361444-66-8

C28H39N3O3