ChemicalBook > CAS DataBase List > LCI699

LCI699

Product Name: LCI699
CAS No.: 928134-65-0
Chemical Name: LCI699
Synonyms: Osilodrostat;LCI699;CS-2488;LCI 699NX;Osilodrostat (LCI699);LCI-699 (Osilodrostat);Isturisa (Osilodrostat);Osilodrostat, 10 mM in DMSO;Osilodrostat(LCI699) free base;(R)-4-(6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile
CBNumber: CB32628027
Molecular Formula: C13H10FN3
Formula Weight: 227.24
MOL File: 928134-65-0.mol

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LCI699 Property

Boiling point:: 433.8±45.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
solubility: DMSO:147.5(Max Conc. mg/mL);649.1(Max Conc. mM)
Ethanol:72.5(Max Conc. mg/mL);319.05(Max Conc. mM)
form: A solid
pka: 6.97±0.40(Predicted)
color: White to yellow
InChI: InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1
InChIKey: USUZGMWDZDXMDG-CYBMUJFWSA-N
SMILES: C(#N)C1=CC=C([C@@H]2N3C(CC2)=CN=C3)C(F)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6896
Product name: Osilodrostat
Purity: 99.17%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-6896
Product name: Osilodrostat
Purity: 99.17%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-6896
Product name: Osilodrostat
Purity: 99.17%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

Crysdot

Product number: CD11011508
Product name: LCI699
Purity: 95+%
Packaging: 10mg
Price: $352
Updated: 2021/12/16

Crysdot

Product number: CD11011508
Product name: LCI699
Purity: 95+%
Packaging: 25mg
Price: $655
Updated: 2021/12/16

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LCI699 Chemical Properties,Usage,Production

Uses

Osilodrostat is a novel 11-β-hydroxylase inhibitor which may be used in the treatment of Cushing’s syndrome,

in vivo

Osilodrostat (LCI699; 0.1-100 mg/kg; p.o.; once) inhibits aldosterone and corticosterone synthesis in Ang-II- and ACTH-stimulated Sprague Dawley rats^[1].
Osilodrostat (LCI699; 3-100 mg/kg; p.o.; daily, for 52 weeks) reduces mean arterial pressure and prolongs survival in dTG rats^[1].

Animal Model:	Male Ang-II- and ACTH-stimulated Sprague Dawley rats^[1]
Dosage:	0.1, 0.3, 1 and 3 mg/kg (Ang-II-stimulated rats) and 1, 3, 10, 30 and 100 mg/kg (ACTH-stimulated rats)
Administration:	Oral administration; once
Result:	Inhibited the increase in plasma aldosterone concentrations stimulated by Ang II or ACTH in a dose-dependent manner.

Animal Model:	dTG rats^[1]
Dosage:	3, 10, 30 and 100 mg/kg
Administration:	Oral administration; daily, for 52 weeks
Result:	Increased fractional LV (systolic and diastolic) shortening, normalized LV isovolumic relaxation time to RR (IVRT/RR) ratio and myocardial cell size and reduced LV weight in a dose-dependent manner.

LCI699 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LCI699 manufacturers

Career Henan Chemical Co

Product: LCI699 928134-65-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

928134-65-0, LCI699Related Search:

LCI699

Osilodrostat

4-(R)-(6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile

4-[(5R)-6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile

LCI 699NX

Osilodrostat (LCI699)

CS-2488

Osilodrostat(LCI699) free base

Benzonitrile, 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluoro-

Isturisa (Osilodrostat)

(R)-4-(6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile

HAC15 cells,Cushing syndrome,primary human adrenocortical cell cultures,inhibit,LCI-699,Mineralocorticoid Receptor,CYP11B2,Osilodrostat,CYP11B1,LCI 699,Inhibitor,blood pressure

Osilodrostat, 10 mM in DMSO

LCI-699 (Osilodrostat)

928134-65-0