NITD 609

Product Name: NITD 609
CAS No.: 1193314-23-6
Chemical Name: NITD 609
Synonyms: KAE-79;KAE609;NITD 609;Cipargamin-13C6;Cipargamin（ KAE609）;NITD609;CIPARGAMIN;KAE609;Cipargamin, 10 mM in DMSO;(3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methylspiro[1H-indole-3,...;KAE 609,KAE-609,inhibit,Cipargamin,NITD-609,NITD 609,Parasite,Inhibitor;(3r,3's)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one
CBNumber: CB32628193
Molecular Formula: C19H14Cl2FN3O
Formula Weight: 390.24
MOL File: 1193314-23-6.mol

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NITD 609 Property

Boiling point:: 621.3±55.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO: soluble
form: A crystalline solid
pka: 13.87±0.40(Predicted)
color: Light brown to brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7486
Product name: Cipargamin
Purity: 98.30%
Packaging: 2mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-7486
Product name: Cipargamin
Purity: 98.30%
Packaging: 5mg
Price: $216
Updated: 2021/12/16

ChemScene

Product number: CS-7486
Product name: Cipargamin
Purity: 98.30%
Packaging: 10mg
Price: $360
Updated: 2021/12/16

ChemScene

Product number: CS-7486
Product name: Cipargamin
Purity: 98.30%
Packaging: 50mg
Price: $1080
Updated: 2021/12/16

ChemScene

Product number: CS-7486
Product name: Cipargamin
Purity: 98.30%
Packaging: 100mg
Price: $1800
Updated: 2021/12/16

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NITD 609 Chemical Properties,Usage,Production

Uses

Cipargamin (NITD609) is an potent antimalarial compound, with an IC50 of appr 1 nM against P. falciparum.

in vivo

Cipargamin (NITD609) shows favorable pharmacokinetic properties and displays single dose cure efficacy in a malaria mouse model. Cipargamin (100 mg/kg) completely clears P. bergheiinfection in all treated mice, and partial cure (50%) is achieved with a single oral dose at 30 mg/kg^[3].

IC 50

Plasmodium

References

[1] Zhou Y, et al. Spiroindolone that inhibits PfATPase4 is a potent, cidal inhibitor of Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2014;58(3):1789-92. DOI:10.1128/AAC.02225-13
[2] van Pelt-Koops JC, et al. The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector. Antimicrob Agents Chemother. 2012 Jul;56(7):3544-8. DOI:10.1128/AAC.06377-11
[3] Rottmann M, et al. Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 3;329(5996):1175-80. DOI:10.1126/science.1193225

NITD 609 Preparation Products And Raw materials

Raw materials

Preparation Products

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NITD 609 Suppliers

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1193314-23-6, NITD 609Related Search:

NITD 609

(1'R,3'S)-5,7'-Dichloro-6'-fluoro-2',3',4',9'-tetrahydro-3'-methylspiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one

(1'R,3'S)-5,7'-Dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one

KAE609

NITD609;CIPARGAMIN;KAE609

(3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methylspiro[1H-indole-3,...

Cipargamin-13C6

Cipargamin（ KAE609）

KAE 609,KAE-609,inhibit,Cipargamin,NITD-609,NITD 609,Parasite,Inhibitor

Cipargamin, 10 mM in DMSO

KAE-79

(3r,3's)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one

1193314-23-6

C19H14Cl2FN3O