TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01)
- Product Name
- TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01)
- CAS No.
- 552309-42-9
- Chemical Name
- TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01)
- Synonyms
- T16Ainh-A01;inhibitor of TMEM16A;TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01);TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem;inhibit,T16AinhA01,Chloride Channel,T16Ainh-A01,T-16Ainh-A01,T16Ainh A01,Cl-Channels,Inhibitor;2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide;2-((5-Ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide;Acetamide, 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-
- CBNumber
- CB32630099
- Molecular Formula
- C19H20N4O3S2
- Formula Weight
- 416.52
- MOL File
- 552309-42-9.mol
TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) Property
- Melting point:
- 211-212°C (dec.)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 7.20±0.50(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- SML0493
- Product name
- T16Ainh-A01
- Purity
- ≥95% (HPLC)
- Packaging
- 10mg
- Price
- $47.34
- Updated
- 2024/03/01
- Product number
- 613551
- Product name
- TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem
- Packaging
- 5mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 18518
- Product name
- T16A(inh)-A01
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18518
- Product name
- T16A(inh)-A01
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- SML0493
- Product name
- T16Ainh-A01
- Purity
- ≥95% (HPLC)
- Packaging
- 50mg
- Price
- $320
- Updated
- 2024/03/01
TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) Chemical Properties,Usage,Production
Uses
This compound functions as a selective class A inhibitor of the calcium activated chloride channel TMEM16A. Useful in the treatment of hypertension, pain, diarrhea and mucus overproduction.
Uses
T16Ainh-A01 has been used as an inhibitor of transmembrane protein 16A (TMEM16A).
Uses
TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) compound functions as a selective class A inhibitor of the calcium activated chloride channel TMEM16A. Useful in the treatment of hypertension, pain, diarrhea and mucus overproduction.
General Description
An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 μM). Fully blocks CaCC current in salivary gland cells at 10 μM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 μM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.
Biochem/physiol Actions
T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance.
storage
Store at +4°C
TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) Preparation Products And Raw materials
Raw materials
Preparation Products
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