5-cyclopropyl-2-fluoropyridine
- Product Name
- 5-cyclopropyl-2-fluoropyridine
- CAS No.
- 1034467-80-5
- Chemical Name
- 5-cyclopropyl-2-fluoropyridine
- Synonyms
- 5-cyclopropyl-2-fluoropyridine;5-Cyclopropyl-2-flluoropyridine;Pyridine, 5-cyclopropyl-2-fluoro-
- CBNumber
- CB32631324
- Molecular Formula
- C8H8FN
- Formula Weight
- 137.15
- MOL File
- 1034467-80-5.mol
5-cyclopropyl-2-fluoropyridine Property
- Boiling point:
- 207.3±28.0 °C(Predicted)
- Density
- 1.194±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -0.06±0.10(Predicted)
- Appearance
- yellow liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C998003
- Product name
- 5-Cyclopropyl-2-fluoropyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C998003
- Product name
- 5-Cyclopropyl-2-fluoropyridine
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- PC201006
- Product name
- 5-Cyclopropyl-2-fluoropyridine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- PC201006
- Product name
- 5-Cyclopropyl-2-fluoropyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $184
- Updated
- 2021/12/16
- Product number
- 3H32-3-0T
- Product name
- 5-Cyclopropyl-2-fluoropyridine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $184
- Updated
- 2021/12/16
5-cyclopropyl-2-fluoropyridine Chemical Properties,Usage,Production
Synthesis
171197-80-1
411235-57-9
1034467-80-5
General procedure for the synthesis of 5-cyclopropyl-2-fluoropyridine from 2-fluoro-5-iodopyridine and cyclopropylboronic acid: in a dry reaction flask, 2-fluoro-5-iodopyridine (1.12 g, 5 mmol), cyclopropylboronic acid (645 mg, 7.5 mmol), palladium acetate (56 mg, 0.25 mmol), potassium phosphate (3.2 g, 15 mmol) were added in sequence and a solvent mixture of toluene and water (20:1, 21 mL, by volume). The reaction mixture was heated at 100 °C for 4 h with stirring. After completion of the reaction, the reaction mixture was diluted with a solvent mixture of chloroform and isopropanol (3:1, 100 mL, by volume). The organic phase was washed sequentially with saturated aqueous sodium chloride solution and deionized water. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a brown oily crude product. Purification by column chromatography (eluent: hexane solution of 20% ethyl acetate) afforded 5-cyclopropyl-2-fluoropyridine (430 mg, 63% yield) as a light yellow oil. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.99 (d, J = 3 Hz, 1H), 7.39 (td, J = 3, 5 Hz, 1H), 6.79 (dd, J = 3, 8 Hz, 1H), 0.96-1.02 (m, 2H), 0.63-0.69 (m, 2H).
References
[1] Patent: WO2008/76705, 2008, A1. Location in patent: Page/Page column 19
[2] Patent: WO2008/144222, 2008, A2. Location in patent: Page/Page column 13
5-cyclopropyl-2-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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