SAR131675

Product Name: SAR131675
CAS No.: 1092539-44-0
Chemical Name: SAR131675
Synonyms: SAR131675;(Rac)-SAR131675;SAR131675 Racemate;SAR131675/SAR-131675;(R)-2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1;2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-n-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;(-)-2-Amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide;(-)-2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-, (-)-
CBNumber: CB32642551
Molecular Formula: C18H22N4O4
Formula Weight: 358.39
MOL File: 1092539-44-0.mol

More

Less

SAR131675 Property

Melting point:: >206°C (dec.)
Boiling point:: 592.2±50.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), DMSO (Slightly)
pka: 12.20±0.29(Predicted)
form: Solid
color: White to Pale Yellow

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0017270
Product name: SAR-131675
Purity: 95.00%
Packaging: 5MG
Price: $503.32
Updated: 2021/12/16

Matrix Scientific

Product number: 132641
Product name: (R)-2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
Purity: 97%
Packaging: 100mg
Price: $2520
Updated: 2021/12/16

AK Scientific

Product number: SYN1165
Product name: SAR131675
Packaging: 100mg
Price: $3265
Updated: 2021/12/16

Matrix Scientific

Product number: 132641
Product name: (R)-2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
Purity: 97%
Packaging: 200mg
Price: $4500
Updated: 2021/12/16

Adipogen Life Sciences

Product number: SYN-1165-M001
Product name: SAR-131675
Purity: ≥95%
Packaging: 1mg
Price: $205
Updated: 2021/12/16

More

Less

SAR131675 Chemical Properties,Usage,Production

Uses

SAR131675 is a VEGFR-3 inhibitor with IC50 of 20 nM.

Synthesis

42841-64-5

1092523-24-4

1092538-80-1

3 g (10.69 mmol) of 2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro[1,8]diazanaphthalene-3-carboxamide was suspended in 20 mL of methanol in an 80 mL microwave tube. A DMF/Et3N mixture (V/V; 1/1) was added to the suspension followed by argon bubbling for 10 min. 1.83 g (±)-1-methoxy-2-methyl-3-butyn-2-ol (16.03 mmol), 0.081 g CuI (0.43 mmol), and 0.375 g bis(triphenylphosphine)palladium(II) dichloride (0.53 mmol) were added sequentially. The sealed tube was placed in a microwave reactor (CEM Discover model) and heated at 90 °C for 60 min at 100 W power. After completion of the reaction, the mixture was cooled and evaporated to dryness. The residue was dissolved in mixed ethyl acetate/THF solvent and washed with 0.1 N HCl aqueous solution. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. The residue was purified by silica gel column chromatography (dry sample, elution gradient: cyclohexane/ethyl acetate, 30:70 to 20:80) to give 2.49 g of light yellow solid product. The product can be recrystallized from ethanol to give white crystals with a melting point of 211 °C. Mass spectrum (MH+): 358. yield: 65%.1H NMR (DMSO-d6, 400 MHz, δ ppm): δ 11.75 (s, <1H, broad peak); 11.00 (q, 1H, broad peak); 8.45 (d, 1H); 8.00 (s, 1H, broad peak); 7.4 (d, 1H); 5.8 (s, 1H); 4.4 (q, 2H); 3.5 (q, 2H). 2H); 3.5-3.3 (m + s, 5H); 2.8 (d, 3H); 1.45 (s, 3H); 1.2 (t, 3H).

IC 50

VEGFR3

References

[1] Patent: US2010/144757, 2010, A1. Location in patent: Page/Page column 8

SAR131675 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

SAR131675 Suppliers

China 88 India 1 United Kingdom 1 United States 6 Global 96

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Jinan Trio PharmaTech Co., Ltd.

Tel: 0531-88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com
Country: China
ProdList: 1856
Advantage: 62

SYN|thesis med chem P/L

Tel: +86-021-50720296
Fax: +86-021-50720297
Email: service@synkinase.com
Country: China
ProdList: 266
Advantage: 58

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 18930833303 18930833303
Fax: +86 (21) 2024-2659
Email: sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

More

Less

View Lastest Price from SAR131675 manufacturers

Career Henan Chemical Co

Product: SAR131675 1092539-44-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-23

1092539-44-0, SAR131675Related Search:

N-(3-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)-2-(pyridin-2-yl)pyriMidine-5-carboxaMide

SAR131675

SAR131675/SAR-131675

(-)-2-Amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide

(R)-2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1

SAR131675 Racemate

1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-N-methyl-4-oxo-, (-)-

2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl)-n-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

(Rac)-SAR131675

(-)-2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

1092539-44-0