trans/cis Resveratrol-D4 Property

storage temp. 

Store at -20°C

solubility 

DMF: >100 mg/ml,DMSO: >50mg/ml,Ethanol: >50mg/ml,PBS (pH 7.2): <100 μg/ml

form 

Liquid

color 

Colorless to light yellow

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

trans/cis Resveratrol-D4 Chemical Properties,Usage,Production

Description

trans-Resveratrol-d₄ is intended for use as an internal standard for the quantification of trans-resveratrol by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC₅₀s = 15 and 3.7 μM, respectively), but not COX-2 (EC₅₀s = >100 μM and 85 μM, respectively). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; ; EC₅₀ = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC₅₀s = 37, 50, 20, <10, 25, 3.3, and 5 μM, respectively) in vitro and/or ex vivo. It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.

Uses

Resveratrol-d4 is labelled Resveratrol (R150000) which is a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.