16-epi-Latrunculin B Property

Density 

1.178±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: soluble; Ethanol: soluble

form 

A film

pka

11.77±0.60(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P501Dispose of contents/container to..…

16-epi-Latrunculin B Chemical Properties,Usage,Production

Description

16-epi Latrunculin B, first isolated from the Red Sea sponge N. magnifica, is a stereoisomer of the actin polymerization inhibitor, latrunculin B .^1,2 At 5-10 μg/ml, 16-epi latrunculin B can disrupt microfilament activity in an actin disruption assay.² It also demonstrates cytotoxic activity in mouse KA31T and NIH3T3 tumor cells (GI₅₀s = 1 and 4 μg/ml, respectively) and antiviral activity against herpes simplex type 1 virus (ED₅₀ = 1 μg/ml).¹

References

1. Hoye, T.R., Ayyad, S.E.N., Eklov, B.M., et al. Toward computing relative configurations: 16-epi-latrunculin B, a new stereoisomer of the actin polymerization inhibitor latrunculin B J. Am. Chem. Soc. 124(25),7405-7410(2016).
2. Vilozny, B., Amagata, T., Mooberry, S.L., et al. A new dimension to the biosynthetic products isolated from the sponge Negombata magnifica J. Nat. Prod. 67(6),1055-1057(2004).