1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-

ChemicalBook > CAS DataBase List > 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-

1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-

Product Name: 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
CAS No.: 509102-00-5
Chemical Name: 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
Synonyms: MIM1;CS-1192;MIM 1;MIM-1;Inhibitor of Mcl-1;1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-;4-[[[2-(Cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-1,2,3-benzenetriol;inhibit,Bcl-2 Family,Inhibitor of Mcl1,Inhibitor,MIM-1,MIM1,MIM 1,Inhibitor of Mcl 1;1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-
CBNumber: CB32652150
Molecular Formula: C17H21N3O3S
Formula Weight: 347.43
MOL File: 509102-00-5.mol

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1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4- Property

Boiling point:: 559.6±60.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
solubility: insoluble in EtOH; insoluble in H2O; ≥12.15 mg/mL in DMSO
form: A crystalline solid
pka: 7.73±0.45(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19832
Product name: MIM1
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19832
Product name: MIM1
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 19832
Product name: MIM1
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Tocris

Product number: 4762
Product name: MIM1
Packaging: 50
Price: $657
Updated: 2021/12/16

TRC

Product number: M341043
Product name: MIM1
Packaging: 5mg
Price: $195
Updated: 2021/12/16

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1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4- Chemical Properties,Usage,Production

Description

MIM1 is an inhibitor of Mcl-1, an antiapoptotic Bcl-2 family protein with a role in cancer. It selectively engages the canonical groove of Mcl-1, inhibiting its ability to bind BH3 domains (IC₅₀ = 4.7 μM). MIM1 induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells.

Uses

MIM1 binds to MCL-1 and aids in the modulation of cell death, division and differentiation. MIM1 may be used for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders.

References

[1]. cohen na, stewart ml, gavathiotis e, et al. a competitive stapled peptide screen identifies a selective small molecule that overcomes mcl-1-dependent leukemia cell survival. chemistry & biology, 2012, 19(9): 1175-1186.

1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4- Preparation Products And Raw materials

Raw materials

Preparation Products

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509102-00-5, 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-Related Search:

Methylcyclohexane

MIM1

4-[[[2-(Cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-1,2,3-benzenetriol

1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-

MIM 1;MIM-1

CS-1192

Inhibitor of Mcl-1

1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-

inhibit,Bcl-2 Family,Inhibitor of Mcl1,Inhibitor,MIM-1,MIM1,MIM 1,Inhibitor of Mcl 1

509102-00-5