2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
- Product Name
- 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
- CAS No.
- 858474-14-3
- Chemical Name
- 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
- Synonyms
- NSC23925;NSC-23925;NSC23925 HCl;NSC23925,NSC-23925;2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE;2-(4-Methoxyphenyl)-a-2-piperidinyl-4-quinolinemethanol Dihydrochloride;2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride;4-Quinolinemethanol, 2-(4-methoxyphenyl)-α-2-piperidinyl-, hydrochloride;(2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol dihydrochloride;[2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride
- CBNumber
- CB32652756
- Molecular Formula
- C22H25ClN2O2
- Formula Weight
- 384.9
- MOL File
- 858474-14-3.mol
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Property
- storage temp.
- room temp
- solubility
- H2O: soluble5mg/mL (clear solution)
- form
- powder
- color
- white to beige
- Water Solubility
- H2O: 5mg/mL (clear solution)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0372
- Product name
- NSC23925
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $266
- Updated
- 2025/07/31
- Product number
- SML0372
- Product name
- NSC23925
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $115
- Updated
- 2022/05/15
- Product number
- 21947
- Product name
- NSC 23925
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 21947
- Product name
- NSC 23925
- Packaging
- 5mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- 21947
- Product name
- NSC 23925
- Packaging
- 10mg
- Price
- $155
- Updated
- 2024/03/01
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Chemical Properties,Usage,Production
Description
NSC 23925 is a non-substrate inhibitor of P-glycoprotein (P-gp). It selectively reverses multidrug resistance mediated by P-gp over resistance mediated by multidrug resistance-associated protein 1 (MRP1/ABCC1) or breast cancer resistance protein (BCRP/ABCG2). It resensitizes paclitaxel-resistant SKOV3TR and OVCAR-8TR cells to paclitaxel . NSC 23925 reverses P-gp efflux, increasing the intracellular accumulation of P-gp substrates, including calcein AM in multidrug-resistant SKOV3TR and OVCAR-8TR cells. It prevents paclitaxel-induced overexpression of the P-gp gene MDR1 and P-gp protein level increases in OVCAR-8 cells. It also prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model when administered at a dose of 50 mg/kg per day in combination with paclitaxel.
Uses
This molecule shows an ibility to inhibit plasma membrane glycoprotein 1 (Pgp1) in order to counter and even reverse multi-drug resistance (MDR1) in patients diagnosed with cancer.
in vivo
Both saline alone and NSC23925 alone treated tumors grow progressively. The usage of NSC23925 in paclitaxel chemotherapy significantly prolongs anticancer efficacy of paclitaxel[1].
References
[1] ZHENFENG DUAN Francis J H Edwin Choy. NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance.[J]. PLoS ONE, 2009: e7415. DOI: 10.1371/journal.pone.0007415
[2] XIAOQIAN YANG . NSC23925 prevents the emergence of multidrug resistance in ovarian cancer in vitro and in vivo[J]. Gynecologic oncology, 2015, 137 1: Pages 134-142. DOI: 10.1016/j.ygyno.2015.02.002
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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