ChemicalBook > CAS DataBase List > 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride

2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride

Product Name
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
CAS No.
858474-14-3
Chemical Name
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
Synonyms
NSC23925;NSC-23925;NSC23925 HCl;NSC23925,NSC-23925;2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE;2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride;2-(4-Methoxyphenyl)-a-2-piperidinyl-4-quinolinemethanol Dihydrochloride;2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride;4-Quinolinemethanol, 2-(4-methoxyphenyl)-α-2-piperidinyl-, hydrochloride;(2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol dihydrochloride
CBNumber
CB32652756
Molecular Formula
C22H25ClN2O2
Formula Weight
384.9
MOL File
858474-14-3.mol
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2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Property

storage temp. 
room temp
solubility 
H2O: soluble5mg/mL (clear solution)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0372
Product name
NSC23925
Purity
≥98% (HPLC)
Packaging
25mg
Price
$404
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0372
Product name
NSC23925
Purity
≥98% (HPLC)
Packaging
5mg
Price
$115
Updated
2022/05/15
Cayman Chemical
Product number
21947
Product name
NSC 23925
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
21947
Product name
NSC 23925
Packaging
5mg
Price
$105
Updated
2024/03/01
Cayman Chemical
Product number
21947
Product name
NSC 23925
Packaging
10mg
Price
$155
Updated
2024/03/01
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2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Chemical Properties,Usage,Production

Description

NSC 23925 is a non-substrate inhibitor of P-glycoprotein (P-gp). It selectively reverses multidrug resistance mediated by P-gp over resistance mediated by multidrug resistance-associated protein 1 (MRP1/ABCC1) or breast cancer resistance protein (BCRP/ABCG2). It resensitizes paclitaxel-resistant SKOV3TR and OVCAR-8TR cells to paclitaxel . NSC 23925 reverses P-gp efflux, increasing the intracellular accumulation of P-gp substrates, including calcein AM in multidrug-resistant SKOV3TR and OVCAR-8TR cells. It prevents paclitaxel-induced overexpression of the P-gp gene MDR1 and P-gp protein level increases in OVCAR-8 cells. It also prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model when administered at a dose of 50 mg/kg per day in combination with paclitaxel.

Uses

This molecule shows an ibility to inhibit plasma membrane glycoprotein 1 (Pgp1) in order to counter and even reverse multi-drug resistance (MDR1) in patients diagnosed with cancer.

2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Suppliers

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858474-14-3, 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol DihydrochlorideRelated Search:

Propylene oxide 4-PIPERIDINOL, PROPIONATE, HYDROCHLORIDE Propylamine

  • 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
  • 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
  • [2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride
  • NSC23925
  • NSC-23925
  • 4-Quinolinemethanol, 2-(4-methoxyphenyl)-α-2-piperidinyl-, hydrochloride
  • (2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol dihydrochloride
  • NSC23925 HCl
  • 2-(4-Methoxyphenyl)-a-2-piperidinyl-4-quinolinemethanol Dihydrochloride
  • NSC23925,NSC-23925
  • 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
  • 858474-14-3