2-Chloro-3-nitro-4-pyridinecarboxylic acid
- Product Name
- 2-Chloro-3-nitro-4-pyridinecarboxylic acid
- CAS No.
- 353281-15-9
- Chemical Name
- 2-Chloro-3-nitro-4-pyridinecarboxylic acid
- Synonyms
- 2-Chloro-3-nitropyridine-4-carboxylic acid;2-Chloro-3-nitro-4-pyridinecarboxylic acid
- CBNumber
- CB32652837
- Molecular Formula
- C6H3ClN2O4
- Formula Weight
- 202.55
- MOL File
- 353281-15-9.mol
2-Chloro-3-nitro-4-pyridinecarboxylic acid Property
- Boiling point:
- 484.7±45.0 °C(Predicted)
- Density
- 1.702±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.01±0.25(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C612080
- Product name
- 2-chloro-3-nitropyridine-4-carboxylicAcid
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 2038AL
- Product name
- 2-Chloro-3-nitropyridine-4-carboxylicacid
- Packaging
- 250mg
- Price
- $109
- Updated
- 2021/12/16
- Product number
- 2038AL
- Product name
- 2-Chloro-3-nitropyridine-4-carboxylicacid
- Packaging
- 5g
- Price
- $451
- Updated
- 2021/12/16
- Product number
- HCH0196867
- Product name
- 2-CHLORO-3-NITROPYRIDINE-4-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.3
- Updated
- 2021/12/16
- Product number
- 122268
- Product name
- 2-Chloro-3-nitropyridine-4-carboxylicacid
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $826
- Updated
- 2021/12/16
2-Chloro-3-nitro-4-pyridinecarboxylic acid Chemical Properties,Usage,Production
Synthesis
23056-39-5
353281-15-9
General procedure for the synthesis of 2-chloro-3-nitro-4-pyridinecarboxylic acid from 2-chloro-4-methyl-3-nitropyridine: 2-chloro-4-methyl-3-nitropyridine (4.00 g, 23.00 mmol) was dissolved in sulphuric acid (40 ml) at 0 °C and potassium dichromate (8.85 g, 30.00 mmol) was added in batches. The reaction mixture was heated and stirred at 60°C for 8 hours. After completion of the reaction, the mixture was allowed to cool to room temperature and slowly poured into ice water. Multiple extractions were carried out with ethyl acetate (5 x 30 ml). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue was ground with pentane (3 × 5 ml) to afford 2-chloro-3-nitro-4-pyridinecarboxylic acid (4.00 g, 19.70 mmol), which was used for subsequent reactions without further purification.LCMS analysis (Method C): 1.51 min; mass spectrometry (MS): ESI m/z 201.1 [M-1 ]; 1H NMR (400 MHz. DMSO-d6) δ 8.83 (d, J = 5Hz, 1H), 8.03 (d, J = 5Hz, 1H).
References
[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 7-8
[2] Patent: US2016/333009, 2016, A1. Location in patent: Paragraph 0824; 0825
[3] Patent: WO2017/93718, 2017, A1. Location in patent: Page/Page column 80
2-Chloro-3-nitro-4-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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