(6-BroMopyridin-2-yl)acetic acid ethyl ester
- Product Name
- (6-BroMopyridin-2-yl)acetic acid ethyl ester
- CAS No.
- 955369-63-8
- Chemical Name
- (6-BroMopyridin-2-yl)acetic acid ethyl ester
- Synonyms
- Ethyl (6-bromo-2-pyridinyl)acetate;ethyl 2-(6-bromo-2-pyridyl)acetate;2-Pyridineacetic acid, 6-bromo-, ethyl ester;(6-BroMopyridin-2-yl)acetic acid ethyl ester
- CBNumber
- CB32657241
- Molecular Formula
- C9H10BrNO2
- Formula Weight
- 244.09
- MOL File
- 955369-63-8.mol
(6-BroMopyridin-2-yl)acetic acid ethyl ester Property
- Boiling point:
- 297.4±25.0 °C(Predicted)
- Density
- 1.451±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.03±0.12(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- OR958798
- Product name
- Ethyl2-(6-bromopyridin-2-yl)acetate
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 6464AC
- Product name
- Ethyl2-(6-bromopyridin-2-yl)acetate
- Packaging
- 1g
- Price
- $262
- Updated
- 2021/12/16
- Product number
- OR958798
- Product name
- Ethyl2-(6-bromopyridin-2-yl)acetate
- Packaging
- 5g
- Price
- $359
- Updated
- 2021/12/16
- Product number
- HCH0048599
- Product name
- ETHYL 2-(6-BROMOPYRIDIN-2-YL)ACETATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $437.85
- Updated
- 2021/12/16
- Product number
- A127350
- Product name
- Ethyl2-(6-bromopyridin-2-yl)acetate
- Purity
- 95%
- Packaging
- 5g
- Price
- $452
- Updated
- 2021/12/16
(6-BroMopyridin-2-yl)acetic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
5315-25-3
105-58-8
955369-63-8
To a solution of 2-bromo-6-methylpyridine (5.00 g, 29.0 mmol, CAS 5315-25-3) in tetrahydrofuran (THF, 100 mL) was slowly added lithium diisopropylammonium (LDA, 2.0 M, 30.5 mL) at -70 °C. The reaction temperature was maintained at -70 °C and after stirring for 0.5 h, diethyl carbonate (5.26 mL, 43.6 mmol) was added. The reaction mixture was slowly warmed to 20 °C and stirring was continued at this temperature for 4 hours. Upon completion of the reaction, the reaction mixture was washed with deionized water (120 mL) and subsequently extracted with ethyl acetate (3 x 150 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=10:1, v/v) to afford ethyl (6-bromopyridin-2-yl)acetate (5.50 g, 77% yield) as a pale yellow oil.1H NMR (400 MHz, CDCl3) δ=7.50-7.41 (m, 1H), 7.33 (d, J=7.6 Hz, 1H ), 7.21 (d, J=7.6Hz, 1H), 4.11 (q, J=7.2Hz, 2H), 3.75 (s, 2H), 1.20 (t, J=7.2Hz, 3H).
References
[1] Journal of Organic Chemistry, 2018, vol. 83, # 16, p. 9088 - 9095
[2] Patent: WO2018/106636, 2018, A1. Location in patent: Paragraph 00238
[3] Patent: US2016/297762, 2016, A1. Location in patent: Paragraph 0361-0362
(6-BroMopyridin-2-yl)acetic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (6-BroMopyridin-2-yl)acetic acid ethyl ester manufacturers
- Product
- Ethyl (6-bromo-2-pyridinyl)acetate 955369-63-8
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-14