4-BROMO-2-FLUORO-5-METHYLPYRIDINE
- Product Name
- 4-BROMO-2-FLUORO-5-METHYLPYRIDINE
- CAS No.
- 1227577-02-7
- Chemical Name
- 4-BROMO-2-FLUORO-5-METHYLPYRIDINE
- Synonyms
- 4-BROMO-2-FLUORO-5-METHYLPYRIDINE;Pyridine, 4-bromo-2-fluoro-5-methyl-
- CBNumber
- CB32658460
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- 1227577-02-7.mol
4-BROMO-2-FLUORO-5-METHYLPYRIDINE Property
- Boiling point:
- 221.0±35.0 °C(Predicted)
- Density
- 1.592±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 1.05±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B872683
- Product name
- 4-Bromo-2-fluoro-5-methylpyridine
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B872683
- Product name
- 4-Bromo-2-fluoro-5-methylpyridine
- Packaging
- 2.5g
- Price
- $325
- Updated
- 2021/12/16
- Product number
- B872683
- Product name
- 4-Bromo-2-fluoro-5-methylpyridine
- Packaging
- 1g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- Z1862
- Product name
- 4-Bromo-2-fluoro-5-methylpyridine
- Packaging
- 1g
- Price
- $667
- Updated
- 2021/12/16
- Product number
- AS146963
- Product name
- 4-Bromo-2-fluoro-5-methylpyridine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $147
- Updated
- 2021/12/16
4-BROMO-2-FLUORO-5-METHYLPYRIDINE Chemical Properties,Usage,Production
Uses
4-Bromo-2-fluoro-5-methylpyridine has properties and potential for diabetes treatment.
Synthesis
17282-01-8
1227577-02-7
General procedure for the synthesis of 4-bromo-2-fluoro-5-methylpyridine from 2-fluoro-3-bromo-5-methylpyridine: To a solution of 2-fluoro-3-bromo-5-methylpyridine (300 mg, 1.596 mmol) in tetrahydrofuran (THF, 10 mL) was added lithium diisopropylammonium (LDA, 2M, 0.8 mL) at -78°C and the reaction mixture was stirred at - 78 °C for 2 hours with stirring. Upon completion of the reaction, the reaction was quenched with 10 mL of water and extracted with ethyl acetate (EtOAc, 10 mL x 3). The organic phases were combined and concentrated to give the crude product. The crude product was purified by fast chromatography (normal phase, silica gel, petroleum ether: ethyl acetate = 0-100%, UV 254 and UV 280 detection) to afford 4-bromo-2-fluoro-5-methylpyridine (130 mg, 43% yield) as a yellow oil.1H-NMR (400 MHz, CDCl3) δppm: 2.37 (s, 3H), 7.19 (d 1H), 8.05 (s, 1H).
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6691 - 6703
[2] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00181
4-BROMO-2-FLUORO-5-METHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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