7-Methyl-1H-indazole-5-carboxylic acid
- Product Name
- 7-Methyl-1H-indazole-5-carboxylic acid
- CAS No.
- 1031417-41-0
- Chemical Name
- 7-Methyl-1H-indazole-5-carboxylic acid
- Synonyms
- 7-Methyl-1H-indazole-5-carboxylic acid;7-methyl-1H-indazole-6-carboxylic acid;1H-Indazole-5-carboxylic acid, 7-methyl-
- CBNumber
- CB32661015
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 1031417-41-0.mol
7-Methyl-1H-indazole-5-carboxylic acid Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M221005
- Product name
- 7-Methyl-1H-indazole-5-carboxylicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR322740
- Product name
- 7-Methyl-1H-indazole-5-carboxylic acid
- Packaging
- 100mg
- Price
- $133
- Updated
- 2021/12/16
- Product number
- 3727AJ
- Product name
- 7-Methyl-1H-indazole-5-carboxylicacid
- Packaging
- 100mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- OR322740
- Product name
- 7-Methyl-1H-indazole-5-carboxylic acid
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 4H58-1-204
- Product name
- 7-Methyl-1H-indazole-5-carboxylic acid
- Packaging
- 250mg
- Price
- $237
- Updated
- 2021/12/16
7-Methyl-1H-indazole-5-carboxylic acid Chemical Properties,Usage,Production
Synthesis
124-38-9
156454-43-2
1031417-41-0
General procedure for the synthesis of 7-methyl-1H-indazole-5-carboxylic acid from carbon dioxide and 5-bromo-7H-methyl-1H-indazole: To a solution of 5-bromo-7-methylindazole (2.00 g, 9.47 mmol) in anhydrous THF (50 mL) was added NaH (570 mg, 14.25 mmol; 60% suspension in mineral oil) at room temperature. after 20 min. After 20 min, the reaction mixture was cooled to -78 °C, sec-butyllithium (1.4 M in cyclohexane, 17 mL; 23.8 mmol) was added dropwise, and the resulting mixture was stirred at -78 °C for 4 h. The reaction mixture was then purged with a dry CO2 gas (1.4 M in cyclohexane, 17 mL; 23.8 mmol). Subsequently, a dry CO2 gas was bubbled through the reaction mixture for 1 hour while slowly warming to room temperature. The reaction mixture was continued to be stirred overnight at room temperature. After completion of the reaction, the reaction was acidified by adding 1N HCl solution and extracted with EtOAc. The organic layer was washed with saturated aqueous NaCl solution, dried over anhydrous MgSO4, filtered and concentrated. The residue was redissolved in MeOH, filtered and concentrated to give 7-methyl-1H-indazole-5-carboxylic acid as a brown solid (1.445 g, 86.6% yield). The product was confirmed by 1H NMR (DMSO-d6) and LC/MS analysis: 1H NMR (DMSO-d6) δ 8.23 (s, 1H), 8.17 (s, 1H), 7.65 (s, 1H), 2.46 (s, 3H); LC/MS ES+ m/z 177 (MH+).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 2, p. 935 - 942
[2] Patent: WO2008/65508, 2008, A1. Location in patent: Page/Page column 27
[3] Synthetic Communications, 2012, vol. 42, # 13, p. 1914 - 1921
7-Methyl-1H-indazole-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Methyl-1H-indazole-5-carboxylic acid manufacturers
- Product
- 7-Methyl-1H-indazole-5-carboxylic acid 1031417-41-0
- Price
- US $0.37/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10kg，100kg Cherry 0952
- Release date
- 2020-11-29