2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

Product Name: 2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.: 1420998-43-1
Chemical Name: 2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
Synonyms: 2-methoxy-4-methylpyridine-3-boronic acidolester;2-Methoxy-4-methylpyridine-3-boronic Acid Pinacol Ester;(2-METHOXY-4-METHYLPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine;Pyridine, 2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine - [M82820]
CBNumber: CB32664203
Molecular Formula: C13H20BNO3
Formula Weight: 249.11
MOL File: 1420998-43-1.mol

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2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine Property

Boiling point:: 355.1±42.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 4.04±0.20(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M264428
Product name: 2-Methoxy-4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
Packaging: 100mg
Price: $90
Updated: 2021/12/16

Crysdot

Product number: CD11260428
Product name: 2-Methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: 97%
Packaging: 5g
Price: $700
Updated: 2021/12/16

Alichem

Product number: 1420998431
Product name: 2-Methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Packaging: 5g
Price: $780
Updated: 2021/12/16

Chemcia Scientific

Product number: AA10-2078
Product name: 2-Methoxy-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine
Purity: 95%
Packaging: 5G
Price: $1275
Updated: 2021/12/16

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2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine Chemical Properties,Usage,Production

Synthesis

717843-51-1

73183-34-3

1420998-43-1

Synthesis of intermediate Vd: Under argon protection, 3-bromo-2-methoxy-4-methylpyridine Vc (813 mg, 4.02 mmol), bis(pinacolato)diboron (1.12 g, 4.41 mmol), PdCl2(dppf)-DCM (146 mg, 0.20 mmol) and KOAc (1.18 g, 12.0 mmol) were were added to a dry sealed tube followed by dry DMF (10 mL). The reaction mixture was stirred at 100 °C for 1.5 h. After cooling to room temperature, another portion of catalyst (75 mg, 0.092 mmol) was added. The reaction tube was resealed and stirring was continued at 100 °C overnight. After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by evaporation. The residue was dissolved in dichloromethane (DCM) and washed with water. The organic layer was separated, dried with anhydrous MgSO4, filtered and concentrated. Purification by silica gel column chromatography (eluent: cyclohexane/EtOAc, 10% to 20% gradient) afforded the intermediate Vd as a yellow oil (2.14 g, 51% yield).1H NMR (300 MHz, CDCl3) δ 8.00 (d, J = 5.3 Hz, 1H), 6.65 (d, J = 5.3 Hz, 1H), 3.89 (s 3H), 2.33 (s, 3H), 1.40 (s, 12H).

References

[1] Patent: WO2013/14170, 2013, A1. Location in patent: Page/Page column 78-80

2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine Suppliers

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1420998-43-1, 2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridineRelated Search:

2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

(2-METHOXY-4-METHYLPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER

Pyridine, 2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-Methoxy-4-methylpyridine-3-boronic Acid Pinacol Ester

2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine - [M82820]

2-methoxy-4-methylpyridine-3-boronic acidolester

1420998-43-1