tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Product Name: tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.: 1035235-26-7
Chemical Name: tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
Synonyms: tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carbo;tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxyl;tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate;2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1;tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-1H-isoquinoline-2-carboxylate;tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate;2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester
CBNumber: CB32665376
Molecular Formula: C20H30BNO4
Formula Weight: 359.27
MOL File: 1035235-26-7.mol

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tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: I917988
Product name: 2(1H)-Isoquinolinecarboxylicacid,3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-,1,1-dimethylethylester
Packaging: 250mg
Price: $510
Updated: 2021/12/16

AK Scientific

Product number: 0849AA
Product name: tert-Butyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
Packaging: 1g
Price: $251
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0005955
Product name: TERT-BUTYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $495.75
Updated: 2021/12/16

Ark Pharm

Product number: P000231494
Product name: tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 95+%
Packaging: 100mg
Price: $48
Updated: 2021/12/16

Ark Pharm

Product number: P000231494
Product name: tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $83
Updated: 2021/12/16

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tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate Chemical Properties,Usage,Production

Synthesis

215184-78-4

73183-34-3

1035235-26-7

Using N-Boc-5-bromo-1,2,3,4-tetrahydroisoquinoline (2.7 g, 8.7 mmol) and pinacol ester of bisboronic acid (4.39 g, 17 mmol) as the starting material, the reactants were mixed with potassium acetate (2.55 g, 26 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (0.63 g, 0.87 mmol) under the protection of nitrogen. 0.87 mmol) were mixed in 1,4-dioxane (40 mL). The reaction mixture was stirred at 80 °C for 2 h and then cooled to room temperature. Water (30 mL) was added and extracted with ethyl acetate (3 x 20 mL). The organic phases were combined and concentrated under reduced pressure. The residue was purified by fast chromatography (eluent: cyclohexane/ethyl acetate=85:15) to afford the target product tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate as a clear gel (3.25 g, 105% yield).LCMS (formate method) : Retention time 1.51 min, [M+H]+=360.

References

[1] Patent: WO2010/146105, 2010, A1. Location in patent: Page/Page column 86-87
[2] Patent: WO2016/65222, 2016, A1. Location in patent: Page/Page column 57
[3] Patent: WO2010/145202, 2010, A1. Location in patent: Page/Page column 38
[4] Patent: WO2013/134518, 2013, A1. Location in patent: Page/Page column 39
[5] Patent: WO2016/44666, 2016, A1. Location in patent: Paragraph 0589; 0591

tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate Suppliers

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1035235-26-7, tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylateRelated Search:

tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxyl

2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester

2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1

tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carbo

tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-1H-isoquinoline-2-carboxylate

1035235-26-7