1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine
- Product Name
- 1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine
- CAS No.
- 109113-39-5
- Chemical Name
- 1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine
- Synonyms
- 1-(Phenylsulfonyl)-5-azaindole;1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine;1-(benzenesulfonyl)-1H-pyrrolo[3,2-c]pyridine;1H-Pyrrolo[3,2-c]pyridine, 1-(phenylsulfonyl)-
- CBNumber
- CB32665790
- Molecular Formula
- C13H10N2O2S
- Formula Weight
- 258.3
- MOL File
- 109113-39-5.mol
1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine Property
- Melting point:
- 124-125 °C
- Boiling point:
- 480.4±37.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 6.14±0.30(Predicted)
- Appearance
- white solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P399890
- Product name
- 1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 1781AA
- Product name
- 1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine
- Packaging
- 250mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CHM0092961
- Product name
- 1-BENZENESULFONYL-5-AZAINDOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.46
- Updated
- 2021/12/16
- Product number
- 123473
- Product name
- 1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $594
- Updated
- 2021/12/16
- Product number
- SC-36317
- Product name
- 1-benzenesulfonyl-5-azaindole
- Purity
- 95
- Packaging
- 5g
- Price
- $1833
- Updated
- 2021/12/16
1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine Chemical Properties,Usage,Production
Synthesis
271-34-1
98-09-9
109113-39-5
To a solution of 1H-pyrrolo[3,2-c]pyridine (5-azaindole) (1 g, 8.47 mmol, 1.0 eq.) in anhydrous THF (10 mL) was slowly added NaH (60% dispersed in mineral oil) (0.24 g, 10.2 mmol, 1.2 eq.) at 0 °C. The reaction mixture was stirred at 0°C for 30 min. Subsequently, benzenesulfonyl chloride (1.80 g, 10.2 mmol, 1.2 eq.) was added slowly and dropwise at the same temperature. The reaction mixture was gradually warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous NaHCO3 solution (30 mL) and then extracted with ethyl acetate (3 x 30 mL). The organic phases were combined and dried with anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure to give 1-benzenesulfonyl-5-azaindole (1.52 g, 5.88 mmol, 69.4% yield) as a yellow solid. The product was confirmed by NMR hydrogen spectroscopy (400 MHz, CDCl3): δ 6.75 (d, J = 3.6Hz, 1H), 7.48 (t, J = 8Hz, 2H), 7.55-7.61 (m, 2H), 7.89-7.93 (m, 3H), 8.49 (d, J = 6Hz, 1H), 8.88 (s, 1H). Electrospray ionization mass spectrometry (ESIMS) analysis showed a molecular ion peak m/z 259.1 ([M+H]+), which is consistent with the theoretical molecular weight C13H10N2O2S.
References
[1] Synthesis, 2005, # 20, p. 3581 - 3588
[2] Patent: WO2017/23987, 2017, A1. Location in patent: Paragraph 0675; 0676
[3] Patent: WO2017/24003, 2017, A1. Location in patent: Paragraph 0675; 0676
[4] Patent: WO2017/24010, 2017, A1. Location in patent: Paragraph 0622; 0623
[5] Patent: WO2017/23984, 2017, A1. Location in patent: Paragraph 0675
1-(Phenylsulfonyl)-1H-pyrrolo[3,2-c]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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