Ethyl 2-forMylisonicotinate
- Product Name
- Ethyl 2-forMylisonicotinate
- CAS No.
- 21908-08-7
- Chemical Name
- Ethyl 2-forMylisonicotinate
- Synonyms
- 108630;Ethyl 2-forMylisonicotinate;ethyl 2-formylpyridine-4-carboxylate;2-formyl-4-Pyridinecarboxylic acid ethyl ester;4-Pyridinecarboxylic acid, 2-formyl-, ethyl ester;2-forMyl-pyridine-4-carboxylic acid 4-ethyl ester
- CBNumber
- CB32665886
- Molecular Formula
- C9H9NO3
- Formula Weight
- 179.17
- MOL File
- 21908-08-7.mol
Ethyl 2-forMylisonicotinate Property
- Boiling point:
- 288.3±25.0 °C(Predicted)
- Density
- 1.204±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.20±0.10(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E918080
- Product name
- Ethyl2-Formylisonicotinate
- Packaging
- 250mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 120920
- Product name
- Ethyl2-formylisonicotinate
- Purity
- 97%
- Packaging
- 10g
- Price
- $4320
- Updated
- 2021/12/16
- Product number
- CHM0392328
- Product name
- ETHYL-2-FORMYLISONICOTINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.79
- Updated
- 2021/12/16
- Product number
- 1095AB
- Product name
- Ethyl2-formylisonicotinate
- Packaging
- 1g
- Price
- $506
- Updated
- 2021/12/16
- Product number
- 21908087
- Product name
- Ethyl2-formylisonicotinate
- Packaging
- 1g
- Price
- $512.72
- Updated
- 2021/12/16
Ethyl 2-forMylisonicotinate Chemical Properties,Usage,Production
Uses
Ethyl 2-Formylisonicotinate is an intermediate used to synthesize aminoisoindoles as BACE1 inhibitors exhibiting in vivo brain reduction of β-amyloid peptides. It is also used to prepare arylmethylamino analogs of edotecarin as topoisomerase I inhibitors with antitumor activities.
Synthesis
41438-38-4
21908-08-7
General procedure for the synthesis of ethyl 2-formylpyridine-4-carboxylate from ethyl 2,4-pyridinedicarboxylate: to an anhydrous solution of diethylpyridine-2,4-dicarboxylate (20.0 g, 89.6 mmol) in anhydrous tetrahydrofuran (300 mL) was added slowly and dropwise at -78 °C aluminum diisobutyl hydroxide (134.4 mL, 134.4 mmol, 1 mol/L in toluene). After the dropwise addition was completed, the reaction mixture was continued to be stirred at -78°C for 3 hours. Subsequently, the reaction solution was slowly poured into a pre-cooled mixture of acetic acid (50 mL) and water (250 mL) and gradually warmed to room temperature. After continued stirring for 1.5 h, the pH of the mixture was adjusted to 8 with sodium bicarbonate solution at 0 °C. Extraction was carried out with ethyl acetate (500 mL x 5), and the organic layers were combined and dried over anhydrous sodium sulfate and subsequently concentrated. Purification by silica gel column chromatography (petroleum ether: ethyl acetate = 40:1-10:1) afforded the target product ethyl 2-formylisonicotinate (13.0 g, 81% yield). lCMS m/z 180.
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 21, p. 9346 - 9361,16
[2] Patent: WO2016/130396, 2016, A1. Location in patent: Paragraph 0090; 0093; 0094
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1388 - 1409
[4] Collection of Czechoslovak Chemical Communications, 1998, vol. 63, # 2, p. 199 - 204
Ethyl 2-forMylisonicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 2-forMylisonicotinate Suppliers
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 0510-83588313-811 18800520310
- sales@chemshuttle.com
- Country
- China
- ProdList
- 2999
- Advantage
- 62
- Tel
- 18986259541
- Fax
- 027-87840182
- sales@3stc.com
- Country
- China
- ProdList
- 3764
- Advantage
- 58
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3991
- Advantage
- 55
- Tel
- 027-027-87342388 18086026008
- Fax
- 027-87342388
- sales@kaymke.com
- Country
- China
- ProdList
- 3731
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 025-85205967 13951876367
- Fax
- 025-85205967
- shengsaichem@163.com
- Country
- China
- ProdList
- 818
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60