Fostemsavir

Product Name: Fostemsavir
CAS No.: 864953-29-7
Chemical Name: Fostemsavir
Synonyms: CS-1669;BMS663068;BMS 663068;BMS-663068;Fostemsavir;BMS-663068-03;BMS663068 Fostemsavir;Fostemsavir(BMS-663068);Foscarbidopa Impurity 3;Fostemsavir, 10 mM in DMSO
CBNumber: CB32666601
Molecular Formula: C25H26N7O8P
Formula Weight: 583.49
MOL File: 864953-29-7.mol

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Fostemsavir Property

Boiling point:: 904.1±75.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 1.39±0.10(Predicted)
color: White to off-white
InChIKey: SWMDAPWAQQTBOG-UHFFFAOYSA-N
SMILES: C(N1CCN(C(=O)C2=CC=CC=C2)CC1)(=O)C(C1C2C(OC)=CN=C(N3C=NC(C)=N3)C=2N(COP(O)(O)=O)C=1)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1059
Product name: Fostemsavir
Purity: 99.57%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ApexBio Technology

Product number: A3254
Product name: BMS-663068
Packaging: 2mg
Price: $189
Updated: 2021/12/16

ApexBio Technology

Product number: A3254
Product name: BMS-663068
Packaging: 5mg
Price: $336
Updated: 2021/12/16

DC Chemicals

Product number: DC8163
Product name: Fostemsavir(BMS-663068)
Purity: >98%
Packaging: 1g
Price: $2200
Updated: 2021/12/16

Crysdot

Product number: CD31000531
Product name: Fostemsavir(BMS-663068)
Purity: 98+%
Packaging: 5mg
Price: $149
Updated: 2021/12/16

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Fostemsavir Chemical Properties,Usage,Production

Uses

Fostemsavir (Rukobia) is an antiviral drug used to treat HIV-1 infection.

Mechanism of action

Fostemsavir is an HIV attachment inhibitor that selectively inhibits the binding of HIV virus to the CD4 receptor, thereby blocking viral attachment and subsequent invasion steps.

Synthesis

Aryl bromide 36 was subjected to Ullman coupling reaction with 3-methyl-1H-1,2,4-triazole using CuI and N,N-dimethylcyclohexanediamine as catalyst and ligand to generate piperazine 37. Residual copper in the reaction was removed by the addition of ammonium pyrrolidine dithiocarbamate (APDTC). The Ullman coupling product was treated with potassium hydroxide (KOH) and then lithium iodide (LiI) hydrate was added to precipitate the target lithium salt 37 in 67% yield. The phosphoryloxymethyl prodrug group was installed on 37 using di-tert-butyl (chloromethyl) phosphate 38 and triethyl sodium (Et4NI) and potassium carbonate (K2CO3). After the reaction, quenching and extraction were carried out by adding toluene, followed by treatment with brine and sodium bisulfate (NaHSO4) to consume the unwanted N-6 isomer byproduct. Through the above steps, the key intermediate 39 was isolated in 70% yield. The final step was the deprotection of the tert-butyl phosphate ester group in 39, which was hydrolyzed by treatment with acetic acid to expose the phosphate group in fostemsavir. The TRIS salt of fostemsavir was precipitated as a white crystalline solid in 88% yield by adding tris(hydroxymethyl)aminomethane (TRIS) in acetonitrile.

target

HIV-1 gp120

Fostemsavir Preparation Products And Raw materials

Raw materials

Preparation Products

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Fostemsavir Suppliers

China 88 United States 11 Global 99

Kaixin Chemical (Hong Kong) Limited

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Shanghai Boyle Chemical Co., Ltd.

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Chembest Research Laboratories Limited

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Haoyuan Chemexpress Co., Ltd.

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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AdooQ BioScience, LLC

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SHANGHAI SINOCHEMTECH CO.,LTD.

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Shanghai Taibao Pharmaceutical Technology Co., Ltd.

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HangZhou YuHao Chemical Technology Co., Ltd.

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864953-29-7, FostemsavirRelated Search:

BMS 663068

BMS663068

BMS-663068

BMS-663068-03

Fostemsavir(BMS-663068)

Fostemsavir

1-(4-Benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-ethanedione

[3-[2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl]-4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)pyrrolo[2,3-c]pyridin-1-yl]methyl dihydrogen phosphate

BMS663068 Fostemsavir

BMS-663068;BMS 663068;BMS663068

CS-1669

BMS-663068;BMS 663068;BMS663068;FOSTEMSAVIR

1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-

Human immunodeficiency virus,HIV,BMS663068,Inhibitor,inhibit,Fostemsavir,BMS 663068

1-(4-Benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-eChemicalbookthanedione

Foscarbidopa Impurity 3

Fostemsavir, 10 mM in DMSO

864953-29-7

C25H26N7O8P